Also in the experiments with _cardiazol_, _coramin_ and _lobeline_ we restricted ourselves primarily to determining whether injurious effects occurred in the case of relatively large doses. Four cc. of 10 percent coramin as well as 2 cc. of 1 percent lobeline were injected intravenously at various stages of recovery without any marked objective and subjective deterioration of the state of the heart, the breathing, and the general condition. But just as with strophanthin, it is impossible to rule out a possible therapeutically favorable effect because of the small number of experiments. We never observed such an effect. Especially the marked deepening of breathing and of the irritability of the trigeminal nerve which usually sets in very suddenly after coramin (for example, sneezing immediately after the injection) were always missing. Contrary to strophanthin, in the case of which we cannot advise against experimentation by intravenous injection under certain conditions, we believe on theoretical grounds that such experiments with _peripheral circulatory drugs_ which may heighten the vessel tonus are not indicated because of the following considerations: The damage to the heart is to be attributed, among other things, to an overloading, which is caused by a blocking of enlarged vessel areas, aside from an increase in viscosity. If the vessel tonus is further increased in the areas which have remained unimpeded, the conditions for the heart are thereby made worse. The sceptical attitude toward the effect of drugs is strengthened above all by the observation that in the majority of the experiments in which no drugs were given, even the most severe disturbances of the peripheral circulation were reduced remarkably rapidly under intensive heat treatment. In this connection it must be emphasized that besides the recovery of body temperature through heat therapy an unloading of the heart takes place because the blocked areas open up. Contrary to earlier concepts, according to which there was danger of hemorrhage into the periphery during rapid rewarming, and according to which one sought to avoid this hemorrhage by wrapping up the extremities as well as by very slow warming, the “venalous bleeding into the periphery” may be life-saving under some circumstances. An exception, namely, loval pyperacmia after considerable rise in temperature and corresponding reestablishment of circulation has already been described in the reference to the danger in some cases of very prolonged treatment in the light cradle.