1. Patient treated with plasma in addition to chemo-therapy: death rate: zero. 2. Patients receiving chemo-therapy alone: death rate 1.1 percent. 3. Control group consisting of all patients who had not received treatment or who had insufficient treatment or only supportive treatment: death rate 38.3 percent. “The dramatic effect of plasma is still more evident if the shock or collapse cases are segregated and tabulated. There were, in all, 78 severely ill patients in that group. The results in the group showed a mortality rate of 95.8 percent for the control group, 15.8 percent for the chemo-therapy, and no mortality in the group treated with plasma plus chemo-therapy.” _Experimental subjects_: No numbers given, presumably several hundred, nonvoluntary as clinical serial tests. PARTIAL TRANSLATION OF DOCUMENT KARL BRANDT 117 KARL BRANDT DEFENSE EXHIBIT 103 EXCERPTS FROM THE DISSERTATION “INFECTION EXPERIMENTS ON HUMAN BEINGS” BY ALFRED HEILBRUNN OF THE HYGIENE INSTITUTE OF THE WUERZBURG UNIVERSITY, 1937, CONCERNING EXPERIMENTS ON HUMAN BEINGS IN OTHER COUNTRIES _Excerpt from “Infection Experiment on Human Beings”_ Inaugural Dissertation for the Attainment of the Degree of a Doctor of Medicine at the Friedrich-Wilhelm University of Berlin; submitted by: Alfred Heilbrunn, Hofgeismar (Hesse Nassau) 1937 From the Hygiene Institute of Wuerzburg University. (Dean: Professor M. Knorr) Printed by: F. W. Gadow and Son, Hildburghausen. (The pamphlet is in the library of the Erlangen University.) * * * * * _MALARIA_ Infection experiments with malaria take up much space in literature. The desire to acquire an exact knowledge of this disease, so important to various countries, makes this fact appear quite understandable. Therefore, numerous experiments on human beings were carried out even before the discovery of the plasmodium malariae and without knowledge of the transmission by anopheles. In the following enumeration, these experiments will be quoted chronologically, thus giving a picture of how the knowledge of the etiology, the infectiousness and the transmission of malaria, was discovered through infection experiments on human beings. 1. (LV 7) * * * SALISBURY (quoted from Mannaberg: Malaria Diseases, Vienna 1899. Nothnagel, Special Pathology and Therapy II 2.) * * * Experiment: * * * Two * * * men * * * after 12 and 14 days, fell ill with typical tertiana. The same experiment in a second case again turned out a positive result.