As a result of the interest awakened by the tour of the general secretary, fourteen missionaries were put into the field in 1837. In 1838 twenty-three missionaries visited eleven states, including New York, Pennsylvania, Ohio, Michigan, Illinois, Missouri, Kentucky Alabama, and Georgia.[17] They were men of experience in parish labors, but they did not go out to the new country to remain there permanently. They attracted large congregations, however, formed several societies which promised to be permanent, administered the ordinances, established Sunday-schools, and did much to strengthen the churches. In 1839 seven preachers were sent into the west, and at the next anniversary there was an urgent call made by the Association for funds with which to establish a permanent missionary agent in the field. Something more was needed than a few Massachusetts ministers preaching from town to town with no purpose of locating with any of the churches they helped to organize. Ministers for the new churches were urgently demanded, but few men from New England were willing to remove to the west; and, though recruits came from the orthodox churches, this source of supply was not sufficient. The repeated calls made for larger resources with which to carry on the work of domestic missions resulted in meetings held in Boston during the year 1841, at which pledges were made to a fund of $10,000 yearly for five years, to be used for missionary purposes. This sum was secured in 1843 and the next four years, so that larger aid was given to missionary activities and to the building of churches. At the annual meeting of 1849 special attention was given to the subject of domestic missions, and plans were devised for largely extending all the activities in this direction. Much interest was taken in the western work during the following years, and slowly new churches came into existence. In 1849 Rev. Edward P. Bond was sent to San Francisco, where a number of New England people had held lay services and formed a church, and in a few years a strong society had grown up in that city. Mr. Bond also went to the Sandwich Islands; but he was not able to open a mission there, owing to ill-health. In the South the work languished, largely owing to the growth of anti-slavery sentiment in the North, with which Unitarians were generally in sympathy. From 1830 to 1850 the Unitarians were confronted by the greatest opportunity which has ever opened to them for missionary activities. The vast region of the middle west was in a formative state, the people were everywhere receptive to liberal influences, other churches had not been firmly established, and there was urgent demand for leadership of a progressive and rational kind. Here has come to be the controlling centre of American life,--in politics, education, and social power. A few of the leaders saw the opportunity, but the churches were not ready to respond to their appeals.