Venoms: Venomous Animals and Antivenomous Serum-therapeuticsCalmette, A. (Albert)
Science
Venoms: Venomous Animals and Antivenomous Serum-therapeutics
Calmette, A. (Albert)
Antitoxins; Poisonous snakes; Toxins; Venom
The scorpion never stings _backwards_, but always _in front_ of itself.
It delivers stabs with its sting in two distinct ways. For the purpose
of defending itself from attack it elevates its abdomen into a bow, and
then regains its former position by suddenly unbending it. To strike
an animal, such as a spider, which serves it for food, the scorpion
seizes it with its pincers and holds it as in a vice. Then it raises
its abdomen, brings the end of it close to its captive, and, with
a lever-like movement, drives the sting into its body. The victim
immediately becomes paralysed and motionless.[115]
The poison-glands of a _Scorpio occitanus_ from the South of France
contain about 1 to 10 centigrammes of a toxic liquid, capable of
furnishing 10 to 15 per cent. of dry extract. This liquid is decidedly
acid; it reddens litmus paper and is miscible with water.
Its physiological effects are especially intense in the case of the
arthropods upon which the scorpion habitually feeds, and in that of
vertebrates in general. Batrachians, fishes, birds, and mammals are
extremely susceptible to this poison. Half a milligramme of dry extract
injected subcutaneously is sufficient to kill a guinea-pig, and 1
milligramme is lethal to the rabbit.
In poisoned animals there is first observed a period of violent
excitement, accompanied by very acute pains; these are followed by
muscular contractions, and finally by paralysis of the respiratory
muscles, as in the case of intoxication by cobra-venom.
The effects of scorpion-poison, which clearly indicate the presence of
a _neurotoxin_, have been very well described by Valentin,[116] Paul
Bert[117] and Joyeux-Laffuie. Kyes[118] has prepared a _lecithide_ from
scorpion-venom, which hæmolyses red corpuscles as do the lecithides
of cobra-venom, and I myself[119] have established the fact that
the antivenomous serum of a horse vaccinated against cobra-venom
effectively protects mice and guinea-pigs against intoxication by the
venom of _Scorpio occitanus_; this has been verified by Metchnikoff.
There is, therefore, a close affinity between this venom and that of
COLUBRINE snakes.
On the other hand, it has been shown by the investigations of C.
Nicolle and G. Catouillard that the same antivenomous serum has
no effect upon the much weaker venom of the scorpion of Tunis
(_Heterometrus maurus_), which, in the case of man and mammals in
general, scarcely does more than produce a transient œdema at the point
of inoculation.
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