Venoms: Venomous Animals and Antivenomous Serum-therapeuticsCalmette, A. (Albert)
Science
Venoms: Venomous Animals and Antivenomous Serum-therapeutics
Calmette, A. (Albert)
Antitoxins; Poisonous snakes; Toxins; Venom
“About 11 a.m., on Friday, July 23, Jules Bellier, aged 26, was mowing
in a damp spot, when he was bitten in the heel by a large viper
(_Vipera berus_). The bite, which was deep, was situated on the outside
of the foot, 1 cm. behind the malleolus and 3 cm. above the plantar
margin; at this point there were two punctures in the skin, 1 cm.
apart. Directly after the accident the patient left his work, tied his
hankerchief tightly round the lower third of his leg, made the wound
bleed, and came to me with all speed, hopping on one foot for about a
kilometre. When I saw him scarcely twenty minutes had elapsed since
the accident; his general appearance was altered, and his pulse rapid.
The patient had vomited twice; he complained of pains in the head, and
of general weakness, and ’was afraid,’ he said, ‘of fainting.’ The
foot and leg were painful under pressure; a slight tumefaction was
visible in the peri-malleolar region, around the bites, which bled a
little. Forthwith, after washing the wound freely with a solution of
permanganate of potash, I injected 10 c.c. of Calmette’s serum into
the antero-external region of the middle part of the thigh; then I
enveloped the leg in a damp antiseptic dressing as high as the knee.
The patient breathed more freely and plucked up his spirits. After
lying down for quarter of an hour he went home on foot (he lives a
hundred yards from my house).
“In the evening I saw my patient again. He was in bed, with a
temperature of 37·2° C.; pulse 60; no malaise, no headache, no further
vomiting; he had taken a little soup, and a small quantity of alcoholic
infusion of lime-tree flowers. He complained of his leg, which was
swollen as high as the knee; the pain was greater in the calf than at
the malleolus. I applied a damp bandage. The patient had a good night,
and slept for several hours, but still had pain in the leg. On the
following morning, July 24, I found him cheerful, with no fever, and
hungry. Around the bite the œdema had become considerable, and had
extended to an equal degree as high as the instep; the calf and thigh
were swollen, but to a much less extent. I gave a second injection of
10 c.c. of antivenomous serum in the cellular tissue of the abdominal
wall. The day was good; indeed, the patient had no fever at any time;
the spots at which the injections were made were but very slightly
sensitive on pressure. In the evening the general condition of the
patient was satisfactory; he complained most of his calf. Thinking that
a contraction was possible, due to his having hopped along quickly on
one leg after the accident, I ordered him a bath.
“On July 25, the second day after he was bitten, the only symptom still
exhibited by the patient was a somewhat considerable amount of œdema in
the peri-malleolar region and lower third of the leg. This œdema was
slowly and gradually absorbed on the following days.
Public-domain text, read in full here on John Shaqi.
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