Her nephew, Humphrey Earl of Stafford, was slain at the first battle of St. Alban’s, in 1455; his father, Humphrey Stafford, Duke of Buckingham, who married her sister, Anne Neville, perished at the battle of Northampton in 1460; her husband, Richard Plantagenet, Duke of York, when the crown of England was almost within his grasp, and her nephew, Sir Thomas Neville, son of her brother, Richard Neville, Earl of Salisbury, and her husband’s nephew, Sir Edward Bourchier, son of Henry Earl of Ewe, afterwards Earl of Essex, by Isabel his wife, were slain in 1460, at the battle of Wakefield; her brother, the Earl of Salisbury, was taken prisoner there, and put to death; her second son, Edmund Earl of Rutland, although a mere child, was, at the same time, murdered after the battle, by John Lord Clifford; her half-nephew, Sir John Neville, commonly called John Lord Neville, {193a} brother to Ralph Neville, second Earl of Westmoreland, perished in 1461, in the action of Dintingdale, prior to the battle of Towton; her nephew, Sir Henry Neville (son of her brother, George Neville, Lord Latimer), was made prisoner, and put to death after the battle of Banbury, in 1469; {193b} her two nephews, Richard Neville, the great Earl of Warwick, the “proud setter-up and puller-down of kings,” and John Neville, Marquis of Montague, and her husband’s nephew, Humphrey Bourchier, Lord Cromwell, the son of Henry Earl of Ewe and Essex, by Isabel his wife, were slain at the battle of Barnet, in 1471; Edward Prince of Wales, who married her great-niece, Anne Neville, the daughter of her nephew, the great Earl of Warwick, was barbarously murdered, after the battle of Tewkesbury, in the same year; her son George Duke of Clarence, was put to death in the Tower of London, in 1477–8, his wife Isabel, who was her great-niece, having previously died, as was suspected, by poison; her son-in-law, Charles Duke of Burgundy, called Charles the Bold, or Charles the Rash, who married Margaret, her third daughter, after having by his folly and rashness, impaired his power, and placed his dominions in a state of great peril, was slain at the battle of Nancy, in 1476–7; her eldest son, King Edward IV., abandoned a warlike and active life for pleasure and excesses, which cut him off in the prime of manhood, in 1483; the first husband of her niece, Katherine Neville, William Bonvile, Lord Harrington, {194a} was slain at the battle of Wakefield, in 1460, and the second husband of her niece, William Lord Hastings, was beheaded, without even the form of a trial, in 1483; her youngest niece, Margaret Neville, married John de Vere, Earl of Oxford, {194b} who, during many years of his life, was a fugitive or prisoner, whilst she suffered from great poverty, and her son by the Earl of Oxford, died in confinement, in the Tower of London, during her husband’s exile; her son-in-law, Henry Holland, Duke of Exeter, who married her daughter Anne, was attainted for his support of the House of