Among the first and strongest advocates of abolition were =Sarah= and =Angelina Grimke=, the daughters of a family of Salzburgers, who during the 18th Century had immigrated into South Carolina and Georgia. Shocked by the inhuman treatment and cruelties inflicted upon the slaves all round, and suffering intensely from the stand taken by their own relatives, the sisters resolved to fight these abuses. While visiting Philadelphia, Sarah came under the influence of the Quakers, and read the strong protest against slavery, which Pastorius and the settlers of Germantown in 1688 had directed to the Quaker meeting. Returning to her home, Sarah besought her relatives to free their slaves. Failing in this effort, she left her home, joined the Quaker society of the “Friends” in Philadelphia, and in 1835 directed an “Appeal to the Christian Women of the South,” imploring them to become active on behalf of the slaves. This pamphlet aroused such a profound sensation wherever it was read, that when some time afterward Miss Grimke expressed a desire to visit her former home, the mayor of Charleston called upon her mother and informed her that the police had been instructed to prevent her daughter’s landing when the steamer should come into port. He also would see to it that she might not communicate with any person, by letter or otherwise, and that, if she should elude the vigilance of the police and go ashore, she was to be arrested and imprisoned until the return of the vessel. As threats of personal violence were also made, Miss Grimke abandoned her visit, but published soon afterward “An Epistle to the Clergy of the Southern States,” and, at the same time, began to address meetings in Pennsylvania as well as in the New England States, in order to rouse the dormant moral sense of the hearers to protest against the colossal sin of the nation. She was assisted by her sister Angelina and such eloquent speakers as =Lucretia Mott=, =Elizabeth Stanton=, =William Lloyd Garrison= and others. These agitators finally created such a stir, that the conservatives and opponents of abolition decided that they must be silenced. Quite often their meetings were disturbed by mobs; halls were refused them, and violence was threatened. The General Association of Congregational Ministers of Massachusetts passed a resolution censuring the Grimke sisters, and issued a pastoral letter containing a tirade against “female preachers.” But in spite of all efforts, public sentiment in the North in favor of abolition steadily grew, until it became evident that the question could not be settled without an armed conflict.