Such being the intensity of the sexual impulse, it is no wonder that sexual abstinence at the age of maturity affects the nervous system and the whole organism of man, with one sex as well as the other, in such a manner that it often leads to serious disturbances and manias; under certain conditions even to insanity and death. True enough, the sexual instinct does not assert itself with equal violence in all natures, and much can be done towards curbing it by education and self-control, especially by avoiding the excitation resulting upon certain conversations and reading. It is thought that, in general, the impulse manifests itself lighter with women than with men, and that the irritation is less potent with the former. It is even claimed that, with woman, there is a certain repugnance for the sexual act. The minority is small of those with whom physiologic and psychologic dispositions and conditions engender such a difference. "The union of the sexes is one of the great laws of living Nature; man and woman are subject to it the same as all other creatures, and can not transgress it, especially at a ripe age, without their organism suffering more or less in consequence."[59] Debay quotes among the diseases, caused by the inactivity of the sexual organs, satyriasis, nymphomania and hysteria; and he adds that celibacy exercises upon the intellectual powers, especially with woman, a highly injurious effect. On the subject of the harmfulness of sexual abstinence by woman, Busch says:[60] "Abstinence has in all ages been considered particularly harmful to woman; indeed it is a fact that excess, as well as abstinence, affects the female organism equally harmfully, and the effects show themselves more pronouncedly and intensively than with the male organism."