From the commencement of Miss Peale’s painting to her sister’s entrance on the arena as a portrait-painter, for some years, it is believed, she was the only professional lady artist in Philadelphia. The sisters, after having commenced their labors, passed their time alternately in Philadelphia and Baltimore; in the latter city receiving unbounded attention and encouragement from families of the highest respectability. They were not only well received as artists, but were welcomed as friends and hospitably entertained. They were much caressed by the family of the venerable Charles Carroll of Carrollton. Miss Sarah painted in oil a portrait of his daughter, Mrs. Caten. The sisters afterward went to Washington to paint the portrait of General La Fayette, who sat for it at their request. Anna spent the winter of 1819 in the Federal city with her uncle, Charles M. Peale, who went there for the purpose of painting the portraits of many distinguished members of Congress. They worked in the same studio. General Jackson was one of their sitters. Miss Peale retained his portrait, and has it still in her possession. President Monroe also had his likeness taken, and the artists were often hospitably entertained at the “White House” by the President and his amiable wife. During the time of her stay in Washington, Miss Peale had her time filled up with commissions; she painted several of the members of Congress, among whom were Henry Clay and Colonel R. M. Johnson. In the following year Miss Peale again visited Washington. She painted a miniature likeness of that remarkable character, John Randolph of Roanoke. It is now in her possession. So incessant was her application to work, that during the summer she was obliged to travel for the recovery of her health, and to give rest to her eyes. Several times they were attacked with inflammation, and at one time she had cause to dread the total loss of sight. Some time after this period she visited Boston, where she painted several portraits. Daniel Webster sat twice for a miniature, which she never quite finished. In 1829 Miss Peale received the addresses of Rev. Dr. William Staughton, a Baptist clergyman of much learning and distinction. He was about that time elected president of the Theological College at Georgetown, Kentucky. They were married August 27th, 1829, and left Philadelphia for the scene of the husband’s future labors. While they were in the city of Washington, Dr. Staughton was taken ill. He died early in December, in a little more than three months after the marriage. The widow returned to Philadelphia the following spring. She resumed her profession, and painted with as great success as before.