She was born in Bologna about 1640, and, like Artemisia Gentileschi, was the daughter of a painter of the school of Guido Reni, whose follower Elisabetta also became. From the study of her master she seems to have acquired the power to perceive and reproduce the greatest possible beauty with which her subjects could be invested. She worked with such rapidity that she was accused of profiting by her father's assistance, and in order to refute this accusation it was arranged that the Duchess of Brunswick, the Duchess of Mirandola, Duke Cosimo, and others should meet in her studio, on which occasion Elisabetta charmed and astonished her guests by the ease and perfection with which she sketched in and shaded drawings of the subjects which one person after another suggested to her. Her large picture of the "Baptism of Christ" was completed when the artist was but twenty years old. Malvasia gives a list of one hundred and twenty pictures executed by Elisabetta, and yet she was but twenty-five when her mysterious death occurred. In the Pinacoteca of Bologna is the "St. Anthony Adoring the Virgin and Infant Jesus," by the Sirani, which is much admired; several other works of hers are in her native city. "The Death of Abel" is in the Gallery of Turin; the "Charity," in the Sciarra Palace in Rome; "Cupids" and a picture of "Martha and Mary," in the Vienna Gallery; an "Infant Jesus" and a picture called "A Subject after Guido" are in the Hermitage at Petersburg. Her composition was graceful and refined, her drawing good, her color fresh and sweet, with a resemblance to Guido Reni in the half tones. She was especially happy in the heads of the Madonna and the Magdalene, imparting to them an expression of exalted tenderness. Her paintings on copper and her etchings were most attractive; indeed, all her works revealed the innate grace and refinement of her nature. Aside from her art the Sirani was a most interesting woman. She was very beautiful in person, and the sweetness of her temper made her a favorite with her friends, while her charming voice and fine musical talent added to her many attractions. Her admirers have also commended her taste in dress, which was very simple, and have even praised her moderation in eating! She was skilled in domestic matters and accustomed to rise at dawn to attend to her household affairs, not permitting her art to interfere with the more homely duties of her life. One writer says that "her devoted filial affection, her feminine grace, and the artless benignity of her manners rounded out a character regarded as an ideal of perfection by her friends." It may be that her tragic fate caused an exaggerated estimate to be made of her both as a woman and an artist. The actual cause of her death is unknown. There have been many theories concerning it. It was very generally believed that she was poisoned, although neither the reason for the crime nor the name of its perpetrator was known.