Inferences drawn correctly according to the Doctrine of Chances depend ultimately on causation. This is clearest, when, as sometimes, the probability of an event is deduced from the frequency of the occurrence of the causes. When its probability is calculated by merely counting and comparing the number of cases in which it has occurred with those in which it has not, the law, being arrived at by the Method of Agreement, is only empirical. But even when, as indeed generally, the numerical data are obtained in the latter way (since usually we can judge of the frequency of the causes only through the medium of the empirical law, which is based on the frequency of the effects), still then, too, the inference really depends on causation alone. Thus, an actuary infers from his tables that, of any hundred living persons under like conditions, five will reach a given age, not simply because that proportion have reached it in times past, but because that fact shows the existence there of a particular proportion between the _causes_ which shorten and the causes which prolong life to the given extent. CHAPTER XIX. THE EXTENSION OF DERIVATIVE LAWS TO ADJACENT CASES. Derivative laws are inferior to ultimate laws, both in the extent of the propositions, and in their degree of certainty within that extent. In particular, the uniformities of coexistence and sequence which obtain between effects depending on different primæval causes, vary along with any variation in the collocation of these causes. Even when the derivative uniformity is between different effects of the same cause, it cannot be trusted to, since one or more of the effects may be producible by another cause also. The effects, even, of derivative laws of _causation_ (resulting, i.e. the laws, from the combination of several causes) are not independent of collocations; for, though laws of causation, whether ultimate or derivative, are themselves universal, being fulfilled even when counteracted, the peculiar probability of the latter kind of laws of causation being counteracted (as compared with ultimate laws, which are liable to frustration only from one set of counteracting causes) is fatal to the universality of the derivative uniformities made up of the sequences or coexistences of their effects; and, therefore, such derivative uniformities as the latter are to be relied on only when the collocations are known not to have changed.