It is interesting, on the occasion of this centenary, to glance back at the position of science and scientific literature in the world’s intellectual life in the early part of the nineteenth century, and to consider briefly the marvelous record of combined scientific and industrial progress of the hundred years following—subjects to be handled in detail in the succeeding chapters. It is fitting also that we should recall the man who founded the Journal, the conditions under which he worked, and the difficulties he encountered. Finally, we must review, but more briefly, the subsequent history of what has so often been called after its founder, “Silliman’s Journal.” The nineteenth century, and particularly the hundred years in which we are now interested, must always stand out in the history of the world as the period which has combined the greatest development in all departments of science with the most extraordinary industrial progress. It was not until this century that scientific investigation used to their full extent the twin methods of observation and experiment. In cases too numerous to mention they have given us first, a tentative hypothesis; then, through the testing and correcting of the hypothesis by newly acquired data, an accepted theory has been arrived at; finally, by the same means carried further has been established one of nature’s laws. _Early Science._—Looking far back into the past, it seems surprising that science should have had so late a growth, but the wonderful record of man’s genius in the monuments he erected and in architectural remains shows that the working of the human mind found expression first in art and further man also turned to literature. So far as man’s thought was constructive, the early results were systems of philosophy, and explanations of the order of things as seen from within, not as shown by nature herself. We date the real beginning of science with the Greeks, but it was the century that preceded Aristotle that saw the building of the Parthenon and the sculptures of Phidias. Even the great Aristotle himself (384–322 B. C.) though he is sometimes called the “founder of natural history,” was justly accused by Lord Bacon many centuries later of having formed his theories first and then to have forced the facts to agree with them.