Our standpoint in the early years of the nineteenth century, just before the American Journal had its beginning, may be briefly summarized as follows: A desire for knowledge was almost universal and, therefore, also a general interest in the development of science. Mathematics was firmly established and the mathematical side of astronomy and natural philosophy—as physics was then called—was well developed. Many of the phenomena of heat and their applications, as in the steam engine of Watt, were known and even the true nature of heat had been almost established by our countryman, Count Rumford; but of electricity there were only a few sparks of knowledge. Chemistry had had its foundation firmly laid by Priestley, Lavoisier, and Dalton, while Berzelius was pushing rapidly forward. Geology had also its roots down, chiefly through the work of Hutton and William Smith, though the earth was as yet essentially an unexplored field. Systematic zoology and botany had been firmly grounded by Buffon, Lamarck and Cuvier, on the one hand, and Linnæus on the other; but of all that is embraced under the biology of the latter half of the nineteenth century the world knew nothing. The statements of Silliman in his Introductory Remarks in the first number, quoted in part on a following page, put the matter still more fully, but they are influenced by the enthusiasm of the time and he could have had little comprehension of what was to be the record of the next one hundred years. Now, leaving this hasty and incomplete retrospect and coming down to 1918, we find the contrast between to-day and 1818 perhaps most strikingly brought out, on the material side, if we consider the ability of man, in the early part of the nineteenth century, to meet the demands upon him in the matter of transportation of himself and his property. In 1800, he had hardly advanced beyond his ancestor of the earliest civilization; on the contrary, he was still dependent for transportation on land upon the muscular efforts of himself and domesticated animals, while at sea he had only the use of sails in addition. The first application of the steam engine with commercial success was made by Fulton when, in 1807, the steamboat “Clermont” made its famous trip on the Hudson River. Since then, step by step, transportation has been made more and more rapid, economical and convenient, both on land and water. This has come first through the perfection of the steam engine; later through the agency of electricity, and still further and more universally by the use of gasolene motors. Finally, in these early years of the twentieth century, what seemed once a wild dream of the imagination has been realized, and man has gained the conquest of the air; while the perfection of the submarine is as wonderful as its work can be deadly.