But there are divers other things which witness, that the true cause of this motion of the bloud is that which I have related. As first, The difference observed between that which issues out of the veins, and that which comes out of the arteries, cannot proceed but from its being rarified and (as it were) distilled by passing thorow the heart: its more subtil, more lively, and more hot presently after it comes out; that is to say, being in the arteries, then it is a little before it enters them, that is to say, in the veins. And if you observe, you will finde, that this difference appears not well but about the heart; and not so much in those places which are farther off. Next, the hardnesse of the skin of which the artery vein and the great artery are composed, sheweth sufficiently, that the bloud beats against them more forcibly then against the veins. And why should the left concavity of the heart, and the great artery be more large and ample then the right concavity, and the arterious vein; unless it were that the bloud of the veinous artery, having bin but onely in the lungs since its passage thorow the heart, is more subtil, and is rarified with more force and ease then the bloud which immediately comes from the _vena cava_. And what can the Physicians divine by feeling of the pulse, unlesse they know, that according as the bloud changeth its nature, it may by the heat of the heart be rarified to be more or lesse strong, and more or lesse quick then before. And if we examine how this heat is communicated to the other members, must we not avow that 'tis by means of the bloud, which passing the heart, reheats it self there, and thence disperseth it self thorow the whole body: whence it happens, that if you take away the bloud from any part, the heat by the same means also is taken a way. And although the heart were as burning as hot iron, it were not sufficient to warm the feet and the hands so often as it doth, did it not continue to furnish them with new bloud. Besides, from thence we know also that the true use of respiration is to bring fresh air enough to the lungs, to cause that bloud which comes from the right concavity of the heart, where it was rarified, and (as it were) chang'd into vapours, there to thicken, and convert it self into bloud again, before it fall again into the left, without which it would not be fit to serve for the nourishment of the fire which is there. Which is confirm'd, for that its seen, that animals which have no lungs have but one onely concavity in the heart; and that children, who can make no use of them when they are in their mothers bellies, have an opening, by which the bloud of the _vena cava_ runs to the left concavity of the heart, and a conduit by which it comes from the arterious vein into the great artery without passing the lungs.