I appeal to American _females_. As mothers, wives and daughters, you have it in your power (without turning aside from your appropriate duties) to put an end to the use of this disgusting weed. The children and youth of this nation, to say nothing of the young men and fathers, are almost exclusively under your control; and may be moulded at your pleasure. You know how _filthy_, _disgusting_, _ruinous_, is the practice against which we ask you to set your faces. Only practice ENTIRE ABSTINENCE yourselves, and urge this practice upon all within your reach; and in less than twenty years, this reformation will be completed. We put the question to every mother, wife, daughter: _will you do it_? I appeal to the _medical_ profession. You are the guardians of the health of the republic. You are acquainted with the deadly properties of the drug in question. You can understand the necessity, and appreciate the importance of reform. You know that _entire abstinence_ is urged by paramount considerations. In the work of reform from spirit-drinking, you have acted in a manner that reflects honor upon your profession. In the work of reform now urged upon your notice, we calculate upon your active, hearty co-operation. If you put your hand to this work, by _precept_, and by _example_; if you abstain _entirely_, and _forever_, from all use of this plant, and inculcate entire abstinence, as you have opportunity; the work which now bespeaks your attention will soon be done. We put the question to every medical man: _will you do it_? Finally--I appeal to _ministers_ of the Gospel. You are stationed on the watch-towers of Zion, as guardians of the public morals. Against every abomination your great Master requires you to cry aloud and spare not; to lift up your voice like a trumpet; to show the people their transgressions, and the house of Jacob their sins. He requires you to be _examples_ to the flock, in all things, that, while "You allure to brighter worlds,"