To an individual unacquainted with the fact, it would seem incredible that a weed, possessed of properties so poisonous, should ever have been sought as an article of luxury. Yet it has not only been sought, but even credulity startles at the extent to which it has been used. "Like opium, it calms the agitations of our corporeal frame, and soothes the anxieties and distresses of the mind." Its powers are felt and its fascinations acknowledged, by all the intermediate grades of society, from the sot who wallows in the mire of your streets, to the clergyman who stands forth a pattern of moral excellence, and who ministers at the altar of God. For it the Arab will traverse, unwearied, his burning deserts; and the Icelander risk his life amidst perpetual snows. Its charms are experienced alike, by the savage who roams the wilds of an American forest, and the courtier who rolls in luxury and prescribes rules of refinement to the civilized world; by the miscreant who wrings from the cold hand of charity the pittance that sustains his life, and the monarch who sways his sceptre over half the globe; by him who is bent with woes and years, and him whose cheek is covered yet with boyhood's down. Hence we might conclude it capable of giving strength to the weary, vivacity to the stupid, and wisdom to men void of understanding; capable of soothing the sorrows of the afflicted, of healing the wounds of the spirit, and assuaging the anguish of a broken heart. But how it fulfils these desirable indications, will be our next business to inquire. Tobacco, as a luxury, has been used for the two last centuries over all the civilized, and the greater portion of the uncivilized world. The modes have been _snuffing_, _smoking_, and _chewing_. Its effects, when habitually used in each of these modes, will now be examined. As far as my observations extend, few, if any, of all the devotees to this stupefying substance, ever resort to its use without some supposed necessity; and often, alas _too often_, by the advice of physicians. The benefit to be derived from the exhibition of a medicine in the cure of disease, should not alone induce us to prescribe it, without due regard to the injury which may result to the constitution. Had this rule been observed relative to the subject under consideration, I apprehend the use of this baneful drug would have been less extensive.