The general tendency of the pamphlet is excellent: and I most cordially give my opinion in its favor: for I have often had occasion to observe the pernicious effects of the free use of tobacco. Many instances of dyspepsia have come under my notice, the origin of which was traced to the practice of _chewing_; and on the abandonment of the habit, the patients were restored to health. I have seen a number of cases of injury to the voice, from the introduction of _snuff_ into the _facial sinuses_. As to _smoking_, I am well satisfied that it is calculated to cause a feverish state of the body; and in certain constitutions it weakens the membranes which line the nostrils, throat, and lungs, produces a susceptibility to colds, and even more serious affections of these parts, when it has been much employed. From what I have seen, I have been led to believe that this article is not necessary nor useful for the preservation of health; and that it is often a cause of weakness and sickness. I am, with great respect, Your ob't serv't, JOHN C. WARREN. _Boston, Jan. 25, 1832._ NOTE.--Many persons have the opinion that the use of tobacco is a preventive of contagious diseases: because it has been asserted that tobacconists and others living in the midst of the effluvia of this article, are exempted from the attacks of such disorders. The practices above alluded to, have in my opinion, a contrary effect. Those who live constantly in the region of tobacco, by the effect of habit cease to be stimulated and over excited by the diffusion of its lighter particles in the air they breathe. But those who employ it, occasionally, whether in smoking, chewing or snuffing, undergo an excitement, more or less considerable; which is infallibly followed by a proportionate debility, in which state, they would be subject to the attacks of a disease they might otherwise have escaped. J. C. W. * * * * * TRANSCRIBER'S NOTE: Every effort has been made to replicate this text as faithfully as possible, including obsolete and variant spellings and other inconsistencies. Corrections in the text are noted below, with corrections inside the brackets: page 12: typo corrected colorless solution, from which it is precipitated by a tincture of galls. Tobacco yield[yields] its active matter to water and proof spirit, but most perfectly to the latter; long page 17: typo corrected thickening of the voice, is also the unavoidable result of habitual snuff-taking. This disagreeble[disagreeable] consequence is produced, either by partially filling up the page 29: added colon This will appear from the following considerations[:]