A.D. 1736, the lower orders of the population of Seville suffered from privations and disease, especially in the suburban districts, at St. Roque, Calzada, and Bernardo. In the same year, epidemic pestilence raged with great violence, at Grand Cairo, from the 1st of February to the 12th of March: more than 100,000 persons were carried off; 7000 were buried daily for some days. On the 24th of December, the river rose to an extraordinary height. The summer of this year was intensely hot in England, and swarms of gnats were so immense all over the country, especially in Salisbury in Wiltshire, as almost to constitute a plague; they appeared in dense clouds, and ascended above the height of the steeple of the cathedral. Ergotism again broke out in Silesia, in Suborth, and at Wealtemburgh, in Bohemia. Dr. Saine describes the disease as beginning with a disagreeable titillation of the feet, as if ants were creeping on them (formication), which was soon succeeded by a violent cardialgia, or pain in the stomach; the hands were next affected, then the head--many cried out that their hands and feet were on fire: epilepsy was one of the concomitants of the disease. A.D. 1737, a comet was seen, and there was an eruption of Vesuvius. A.D. 1738, another comet was seen in February; drought prevailed in Spain, and famine and pestilence followed: the malady, however, was not of a mortal character. A.D. 1740, epidemic disease was rife in Ireland; it proved fatal to great numbers in the city of Dublin, and continued throughout the following year. Lord Chancellor Jocelyn, writing from Ireland, in the year 1741, to his brother Chancellor, Lord Hardwicke, in England, mentions the distressed state of the country at this period, owing to the entire failure of the potato crops, which was followed by famine and disease to a frightful extent: fevers, attended with convulsions, were epidemic in Germany: and the vomito negro was destructive to the inhabitants of Spain; it prevailed at Malaga, and in many other of its provinces. Pestilence broke out at Tobolsk, in Siberia, first attacking horned cattle and horses, and afterwards human beings; it prevailed in the form of pestilential carbuncle. A.D. 1742–3, two comets were seen. In the archives of the Franciscan Convent of San Diego de Carthagena it is recorded that pestilence prevailed amongst the members, nearly all of whom suffered severely, three only escaping.