A.D. 1761, in the northern parts of the United States of America, severe catarrh or influenza prevailed in the spring; it changed its character to malignant yellow fever during the summer and autumn. This disease was also prevalent in the West Indies. The symptoms were slight cold, followed by extraordinary prostration of strength, laborious respiration, cough, obtuse pains at the precordia and in the chest and limbs. The malady presented the signs of a bilious distemper, the countenance becoming yellow; insensibility or coma, and sometimes delirium, supervened, when the patient was taken off with all the symptoms of a regular bilious plague or yellow fever. About this period a deadly epizootic broke out among the dogs in Madrid; it extended over the entire kingdom: the disease, it would appear, was confined to the canine race, no other kind of domestic animal having suffered from it. The Paving Act, which may be regarded as a useful sanitary measure, was passed in England. A tremendous shock of an earthquake, attended with volcanic eruptions, was experienced in the Azores in the month of April. The year following, A.D. 1762, a comet was visible; and on the 9th of February the river Thames rose to a very great height. The heat and drought this year in the United States of America exceeded all the extraordinary seasons hitherto noticed. The inhabitants were greatly distressed for want of water; bilious remittent fever raged in many of the States in the following autumn, especially in Philadelphia. At the Havannah, about the same period, great mortality was occasioned by a similar epidemic. Pestilence also raged in Siam and in Bengal, in Syria, and in various parts of Egypt. The influence of similar seasons was experienced in England and Ireland, and also in France, where pestilence was rife. The summer of 1763 was moist and sultry; the Indians of Massachusetts and at a place called Martha’s Vineyard in the United States of America were swept away in vast numbers by a yellow or bilious pestilence. An epidemic catarrh called ‘the snuffles’ was very destructive to cattle, especially to horses, in Denmark. Pestilence again prevailed among the canine race at Madrid; the poultry died of it at Genoa, and horned cattle in France, as also in Sweden. This extensive prevalence of epizootic disease indicated a pestilential condition of the atmosphere and a disturbed state of the seasons: the disease first attacked and proved fatal to dumb animals, and afterwards man became its victim: its ravages were attended with great mortality. Malignant fever at this period assailed all Naples, destroying, as has been asserted, 20,000 inhabitants: it was preceded by famine. An earthquake was felt at Comorra, in Hungary; 1500 houses were thrown down, and many lives were lost, the sufferers being buried under the ruins.