A.D. 1764, on the 26th of December, a severe shock of an earthquake was felt at Lisbon: a comet was visible. The treatment of small-pox was greatly modified about this time by the introduction of the cooling regimen, which was first recommended in England by the Suttons. In the same year epidemic pestilence broke out in the principality of Estremadura, and was very fatal: various other parts of Spain suffered from the invasion of a similar disease; it carried off great numbers at Cadiz, and its outbreak was attributed in a great measure to the distresses occasioned by the Portuguese war; it was a miliary fever, attended with glandular swellings, especially of the parotids. Rain fell heavily during the months of April and May in Carthagena, and consequently tertian fevers were prevalent; and there perished of that disease upwards of 2000 persons in the city during those two months. Pestilential disease ravaged Suabia, and both Scotland and Ireland suffered greatly at this time from epidemic pestilence. Lethal epidemic disease prevailed in Austria; and in the greater part of the United States of America bilious remittent fever, similar to that prevalent in the West Indian Islands, carried off vast numbers. The pestilence in Ireland was marked by all the symptoms of bilious remittent or yellow fever. A.D. 1765, on the 4th of June, an earthquake was felt along the banks of the Ganges: a shock was experienced on the 19th of May previously in the Pyrenean mountains. A severe storm occurred on the east coast of Britain, and many seamen perished in consequence. Spital, near Berwick, suffered greatly from this catastrophe.