A.D. 1800, malignant yellow fever commenced at Baltimore, and raged in Boston, and in various other of the principal districts of the Union. In the autumn of this year, Cadiz became desolate from a similar pestilence; by the middle of September the deaths amounted to 200 daily: at this period the air, from its stagnant state, says Arejula, became so vitiated, that its noxious qualities affected even the lower orders of animals: canary birds died with blood issuing from their bills; and in none of the neighbouring towns, which were afterwards infected, did any sparrows appear during the epidemic. We saw, continues Arejula, many of the domestic animals die with some of the same symptoms as those presented by persons labouring under the disease. Dogs were affected by the epidemic more than any other animals; the cats next, and the horses, then poultry and canary birds; dogs and cats were also subject to hemorrhages, but more so to the black vomit, and to dark fœtid evacuations. The horses which I saw die, he says, had that marble coldness of the extremities, or the general convulsions, so remarkable in this disease. Another author, Fellows, states that all the physicians in Cadiz and in Malaga who have written on this disorder, and with whom he had conversed, confirmed to him the facts as detailed by Arejula. The inhabitants of Xeres suffered greatly from this yellow pestilence; it also prevailed at Malaga, and in various other parts of Spain: it persisted unto 1804. A.D. 1801, anginas, pleurisies, and yellow pestilence continued to prevail for several years in the United States of America, and in other places: typhus was rife in Ireland and England, especially in London, from which city and countries it is scarcely ever absent. A.D. 1802, a very hot and dry summer was succeeded in November by incessant heavy rain: thick fogs spread over the country, and enveloped such places in central Germany as were inaccessible to ventilation; amongst others, the small Franconian town of Roettingen, situated on the river Tauber, and surrounded by mountains. Towards the end of the month an extremely fatal disease broke out, which was without example in the memory of its oldest inhabitants, it being totally unknown to them previously. The young and strong were suddenly seized with pain and anguish at the heart, with violent palpitations, and lacerating pains in the nape of the neck; profuse, sour, ill-smelling perspiration broke out over the entire body, and a suffering, as though a violent rheumatic fever had seized on the tendinous expansions, accompanied this terrible malady: in the worst cases a spasmodic trembling ensued, the patient fainted, the limbs became rigid, and death closed the scene, frequently within twenty-four hours from the commencement of the attack.