and with burning fever; in a short time vomiting of a blackish fluid, similar to coffee-grounds, ensued, and in a few hours death closed the scene. A.D. 1842 and 1843, cholera in a sporadic form raged with considerable violence in many parts of Persia, continuing at intervals during the two subsequent years. A.D. 1844, yellow pestilence committed great ravages at Goree, in Senegal. During the year 1845, the blight among the potatoes spread rapidly through Germany, Holland, Belgium, the northern parts of France, and over the greater portion of England, Scotland, and Ireland. This pestilence re-appeared the year following, 1846. A phenomenon worthy of notice was observed during the prevalence of this disease,--to wit, the existence of a mist or fogs immediately previous to the blight in the crops. In Holland, a thick stinking mist, which extended very widely, was observed in 1845, antecedent to the potato blight. M. Petit states that it was generally remarked in France that the disease made its appearance after a fog. In England the same phenomenon was observed. In the spring of 1845 remittent fever broke out on board the ‘Eclair,’ while on the coast of Africa; the first persons attacked being those who had been engaged in boat-service. The vessel at the time lay off the Sherbro’ river, and the boats had been employed for some time exploring its creeks, and those in the Seabar branch of that river. The disease continued to spread among the boats’ crews; and after a while those seamen who had not been out of the ship became subject to the fever, which committed such fearful ravages among them that at last the ‘Eclair’ was ordered home as a _dernier ressort_. The disease then presented all the characters of genuine yellow fever. On the voyage, the ‘Eclair,’ after having been refused pratique at Goree, put in at Boa Vista, one of the Cape de Verd Islands, where the crew were landed, and stayed some days; but the epidemic continued to seize its victims, and the crew consequently, both the sick and sound, were again received on board, and the vessel got under weigh for England. Before she reached Madeira, Captain Estcourt, Dr. M’Clure, and Mr. Hartmann, the assistant surgeon, died, Mr. Machonchy, the surgeon to the ship, expiring the day after. Mr. Sydney Bernard, assistant surgeon of the ‘Growler,’ having volunteered his services, was appointed in Mr. Machonchy’s place, and performed his duties to the last. On the arrival of this floating pest-house in England, pratique was refused, and the healthy, the sick, and the dying were all kept on board. The result was the loss of several more lives, the disease not ceasing until about a fortnight after her arrival at the Motherbank. Mr. Sydney Bernard and Lieutenant Isaacson, the officer in command, were among its latest victims. The deaths on board from the endemic, from first to last, amounted to seventy-four. Fever prevailed very extensively in Boa