evidently confluent small-pox. A.D. 325, epidemic pestilence, preceded by famine, prevailed all over Britain, and in many other parts of the world. During the years 336, 355, 358, 362, 367, 368, and 375, deadly disease, with famine and earthquakes, were again experienced in the British Isles. In Wales alone, in the latter year, 43,000 persons died from pestilence. A terrible earthquake was felt in Macedonia, and 150 cities were swallowed up in Asia and Greece. Ammianus Marcellinus mentions a plague which broke out in Amida, a city of Persia, during its siege by Sapor, which was attributed to the distresses of war, and to the corruption of unburied bodies lying about in the streets, plains, &c. A.D. 361, there was a terrible famine in Italy. Four years after, 365, severe shocks of an earthquake, with inundations round the Mediterranean, did much damage. 50,000 persons were drowned at Alexandria in the month of July. Italy and Syria suffered from plague, which continued until 394. An inundation of the Nile nearly destroyed the cities of Alexandria and Libya; and rain, storms, and drought were experienced in Judea, which was also visited by immense swarms of locusts. These phenomena were succeeded by dire pestilence. There were several earthquakes at intervals between the months of September and November, which destroyed many places in Europe. During the years 400, 407, 417, and 419, pestilence desolated Asia, Africa, and Europe; a severe earthquake shook Cibyra, and destroyed many villages in its neighbourhood: in 419, an earthquake swallowed up several cities in Palestine. A.D. 442, pestilence swept away great numbers in England this year. A.D. 446, on the 17th of September, at Constantinople, a severe earthquake, attended with fire, pestilence, and famine, caused great misery. The walls of the town with seventeen towers were thrown down. A.D. 458, an earthquake destroyed nearly all Antioch on the 14th of September. Pestilence, about the same period, again broke out in England, and in various other regions, as related by Echard. The Greek ecclesiastical historian Nicephorus, and other writers, state that it prevailed more remarkably in Cappadocia, Galatia, and Phrygia. Isodorus tells us that so great were the famine and disease in Spain, in A.D. 443, that men fed with fury upon each other. From the year 450 until 467, pestilence raged in Rome; it revisited the city A.D. 473. The year previously, 472, on the 11th of November, at noon, there occurred an eruption of Vesuvius, which ejected flames that were seen at Constantinople, obscured the sun at noon day, and ravaged all Campania: there were ashes four inches deep on the tops of houses many miles distant. A.D. 480, a severe earthquake was experienced at Constantinople, which lasted forty days, causing much destruction of life and property. Epidemic pestilence infested Scotland; and Asia and Africa were nearly depopulated by epidemic disease.