and in the same summer appeared at Basle, when in the space of eight months it destroyed 2000 persons. Small-pox raged with great mortality at this time in Hispaniola. A.D. 1518. Marselio Ficino, in his work on the plague, written according to Haller in 1518, describes the treatment that was adopted, consisting chiefly in the application of cupping-glasses below the carbuncles. In the city of Cascante, in the kingdom of Navarre, there broke out an epizootic, which caused great destruction among the horses of the regiments quartered there; the principal feature of the pestilence was extensive apostemes on the head and throat, attended with an insatiable thirst and hectic fever. About the period of the earthquakes which were experienced in Xativa A.D. 1517, epidemic disease prevailed in many parts of Spain: it extended subsequently to the city of Valencia, and caused great mortality in 1519. The public authorities, because of the general prevalence of disease and the consequent mortality, withdrew to Murviedro. A.D. 1521, in June, rogatory prayers were offered up in consequence of the dreadful pestilence which ravaged Barcelona. The plague raged at Dresden also. The last plague of Mallorca, of which notice is taken by Don Vincente Mut, occurred in the year 1523. Great numbers were carried off by it. The city of Valencia also suffered from a similar pestilence, which was attributed to atmospheric poison. The year following, 1524, a bubonic pestilence, as it was termed, raged with great fierceness, and carried off 50,000 of the inhabitants of Milan. The plague was also rife in the city of Xativa, and the greatest pestilence from which the city of Seville ever suffered, occurred about this time, and persisted for some years. A.D. 1525, the sweating sickness, which had been for some time raging in England, extended to other parts of Europe, and in the course of five years spread over Lower Germany, the Low Countries, Holland, Zealand, Brabant, Flanders, Denmark, Norway, and France. So rapid was this disease, that on making its appearance in any place, it would seize on 600 and upwards in a day, while of this number, when so seized, rarely more than six recovered, so destructive was it. The distemper was generally supposed to have been caused by some poisonous quality of the atmosphere.