Orosius, another Spanish writer, and also Dionysius, relate the occurrence of a terrible plague at Rome, which caused great mortality, 463 B.C. This was a grievous time, says the historian, men and beasts being equally afflicted. The disease was preceded by great heat and drought, and the calamities and fatigues of war, which were greatly augmented by crowds of countrymen and herds of cattle received within the walls of the city, in order to avoid the ravages and plunderings of the Latins and Hernici, who then desolated the country. The epidemic first seized on horses and horned cattle, then on man, the poorer people being the chief victims: it began about the calends of September, and raged until the end of November. The two consuls Servilius and Æbutius, and many other illustrious Romans, fell victims to the disease. Livy and Dionysius inform us that, anno 452 B.C., nearly one-half of the inhabitants of Rome were destroyed by the pestilence _loimikié_, which was also communicated to the Æqui, the Volsci, and the Sabines, and caused a great mortality amongst them. The distress and consternation being general, the land was left uncultivated, and the miseries of famine threatened to overwhelm those who survived the epidemic. This pestilence was succeeded by another, which, if possible, was more grievous; it lasted from 443 to 438 B.C. In time, so frequently had Rome been scourged by repeated epidemic pestilences, that Livy styled it “urbs assiduis exhausta funeribus.” In the second year of the Peloponnesian War, 435 B.C., epidemic pestilence broke out at Athens, where the inhabitants of the Athenian territory were crowded together into the city to avoid the ravages of the Lacedemonians: it destroyed 5000 of the prime of their armies, and an immense number of the poor, and continued without interruption for five years. It began towards the close of an open spring, after a severe winter, raged the four following summers and autumns, was especially fatal to their armies at the siege of Epidaurus and Potidea, and continued all through the severe winters. Thucydides, Lucretius, Anacharsis, Plutarch, and Hippocrates give an account of a similar pestilence which ravaged Persia about the same period. Artaxerxes, the king of Persia, sent for the great physician of Cos and Greece to come and arrest its progress, but Hippocrates nobly answered the Persian monarch in these words, addressing Hystaspes, prefect of the Hellespont: “To the epistle which you have sent, and you have asserted to come from the king, write to the king as I briefly answer,--We enjoy victuals, clothing, homes, and everything necessary for life in abundance; and it is neither right for me to use the wealth of the Persians, nor to liberate barbarians from diseases while they may be the enemies of Greece. Farewell.” Thucydides describes the symptoms of the disease in a cursory manner; Lucretius more minutely; and from these historians we infer the following morbid phenomena.