A.D. 1541, pestilence raged with great violence in Constantinople, and carried off vast numbers. The year following, 1542, clouds of red locusts, which came from Turkey, passed over Sclavonia, Croatia, Austria, and Italy, and alighted in Spain in such numbers that they destroyed every green thing. About this period the celebrated Andres Laguna proposed for the cure of the plague an infusion of carlina (white thistle), a drachm of which, after it had been infused, was to be taken daily. A.D. 1543, epidemic pestilence visited the city of Metz, causing a frightful mortality. Two years after, 1545, a pestilential epidemic, similar to that which prevailed so extensively A.D. 1528, called ‘la trousse galante,’ made its appearance in various parts of Europe, slaying the robust and young; it was equal in awfulness and mortality to the pestilence which in the days of Moses destroyed the first-born of Egypt: the disease first appeared in Savoy, and over a great part of France; it continued until the following year, 1546. Parè, and a Flemish physician, Sanders, describe the symptoms of this malady, which was attended, as in 1528, with the loss of the hair and of the nails: its attack was rapid and very fatal. Patients at the onset suffered from an overwhelming weight in the body, and a violent headache, which soon deprived them of all consciousness; and stupor ensued, with relaxation or loss of power of the sphincter muscles: in most cases an eruption was observed, of which no mention is made in former outbreaks of the malady; Sanders does not, however, distinctly state its nature. 10,000 English residents died from pestilence in the course of this year and the year following at Boulogne. The bubonic plague made its appearance in the Netherlands. A.D. 1547, heavy rains inundated Tuscany. Pestilence raged all over Europe, especially in England, Holland, and Germany. The city of Dresden also suffered from it. Mould-spots and red water were observed in the north of Germany. The year following, pestilence continued in England and also in Prussia, causing great mortality in both countries. The kingdom of Murcia suffered from epidemic disease, and the question arose, as had been frequently the case before, whether the disease was contagious or not: great difference of opinion thereon prevailed. Portugal also suffered about this period from pestilence. A.D. 1549, vast numbers of caterpillars appeared in Germany and destroyed all the herbage; they were followed by pestilence, especially in the North, where petechial fever destroyed great numbers.