One form of epidemic malady, intimately connected with bad harvests and a poor state of agriculture, namely Ergotism, from the mixture of poisoned grains in the rye or other corn, is conspicuously missed from English records of the medieval period, although it plays a great part in the history of French epidemics of the Middle Ages, under such names as _ignis sacer_, _ignis S. Antonii_, or _ignis infernalis_. According to the proverbial saying already quoted, France was as notorious for _ignis_ as England for famine, and Normandy for lepra: “Tres plagae tribus regionibus appropriari solent, Anglorum fames, Gallorum ignis, Normannorum lepra[111].” The malady was of a nature to attract notice and excite pity; it is entered by chroniclers, and is a frequent topic in French legends of the Saints. Its occurrence in epidemic form can be traced in France, with a degree of probability, as far back as 857 (perhaps to 590); six great outbreaks are recorded in the tenth century, seven in the eleventh, ten in the twelfth, and three in the thirteenth, the medieval series ending with one in the year 1373. The estimates of mortality in the several epidemics of ergotism over a larger or smaller area of France, range as high as 40,000, and 14,000, which numbers may be taken to be the roughest of guesses; but in later times upwards of 500 deaths from ergotism have been accurately counted in a single outbreak within a limited district. The epidemics have been observed in particular seasons, sometimes twenty years or more elapsing without the disease being seen; they have occurred also in particular provinces--in the basin of the Loire, in Lorraine, and, since the close of the medieval period, especially in the Sologne. The disease has usually been traced to a spoiled rye crop; but there is undoubted evidence from the more recent period that a poison with corresponding effects can be produced in some other cereals, even in wheat itself.