The Middle Age of European history has no naturally fixed beginning or ending. The period of Antiquity may be taken as concluded by the fourth Christian century, or by the fifth or by the sixth; the Modern period may be made to commence in the fourteenth, or in the fifteenth or in the sixteenth. The historian Hallam includes a thousand years in the medieval period, from the invasion of France by Clovis to the invasion of Italy by Charles VIII. in 1494. We begin, he says, in darkness and calamity, and we break off as the morning breathes upon us and the twilight reddens into the lustre of day. To the epidemiologist the medieval period is rounded more definitely. At the one end comes the great plague in the reign of Justinian, and at the other end the Black Death. Those are the two greatest pestilences in recorded history; each has no parallel except in the other. They were in the march of events, and should not be fixed upon as doing more than their share in shaping the course of history. But no single thing stands out more clearly as the stroke of fate in bringing the ancient civilization to an end than the vast depopulation and solitude made by the plague which came with the corn-ships from Egypt to Byzantium in the year 543; and nothing marks so definitely the emergence of Europe from the middle period of stagnation as the other depopulation and social upheaval made by the plague which came in the overland track of Genoese and Venetian traders from China in the year 1347. While many other influences were in the air to determine the oncoming and the offgoing of the middle darkness, those two world-wide pestilences were singular in their respective effects: of the one, we may say that it turned the key of the medieval prison-house; and of the other, that it unlocked the door after eight hundred years.