Renewals of it are heard of in one part of Europe or another until the end of the sixth century, when its continuity is lost. But it is clear that the seeds of pestilence were not wanting in Rome and elsewhere in the centuries following. Thus, about the year 668, the English archbishop-elect, Vighard, having gone to Rome to get his election confirmed by the Pope Vitalianus, was shortly after his arrival cut off by pestilence, with almost all who had gone with him[2]. Twelve years after, in 680, there was another severe pestilence in the months of July, August and September, causing a great mortality at Rome, and such panic at Pavia that the inhabitants fled to the mountains[3]. In 746 a pestilence is said to have advanced from Sicily and Calabria, and to have made such devastation in Rome that there were houses without a single inhabitant left[4]. The common name for all such epidemics is _pestis_ or _pestilentia_ or _magna mortalitas_, so that it is open to contend that some other type than bubo-plague, such as fever or flux, may have been at least a part of them; but no type of infection has ever been so mortal as the bubo-plague, and a mortality that is distinguished by a chronicler as causing panic and devastation was presumably of that type. Pestilence in England and Ireland in the Seventh Century. It is more than a century after the first great wave of pestilence had passed over Europe in the reign of Justinian, before we hear of a great plague in England and Ireland. Dr Willan, the one English writer on medicine who has turned his erudition to that period, conjectures that the infection must have come to this country from the continent at an earlier date. From the year 597, he says, the progress of conversion to the Christian religion “led to such frequent intercourse with Italy, France and Belgium, that the epidemical and contagious disease prevailing on the continent at the close of the sixth century must necessarily be communicated from time to time through the Heptarchy[5].” Until we come to the _Ecclesiastical History_ of Beda, the only authorities are the Irish annals; and in them, the first undoubted entry of a great plague corresponds in date with that of Beda’s history, the year 664. It is true, indeed, that the Irish annals, or the later recensions of them, carry the name that was given to the plague of 664 (_pestis ictericia_ or _buide connaill_) back to an alleged mortality in 543, or 548, and make the latter the “first _buide connaill_”; but the obituary of saints on that occasion is merely what might have occurred in the ordinary way, and it is probable, from the form of entry, that it was really the rumour of the great plague at Byzantium and elsewhere in 543 and subsequent years that had reached the Irish annalist[6].