That the ancients were accustomed to clarify their wine with gypsum, is proved by different passages of the Greek writers on husbandry. They threw gypsum into their new wine; stirred it often round, then let it stand for some time, and, when it had settled, poured off the clear liquor[732]. It would, however, appear that they had remarked that gypsum caused the spirituous part to disappear; for we read that the wine acquired by it a certain sharpness which it afterwards lost, but that the good effects of the gypsum were lasting[733]. This process in modern times has been publicly forbidden, in many countries, as it was in Spain in the year 1348. Calcined shells were in ancient times used instead of lime[734]. Potters-earth was also thrown into wine, in order to clarify it by carrying the muddy particles with it to the bottom. This method I have seen employed in the breweries at Amsterdam, to purify the water. In the south of France it is used for clarifying wine-stone ley; and in my opinion it might be useful on many other occasions[735]. The ancients poisoned their wine with lead without knowing it; but at what period did that pernicious practice begin of employing sugar of lead and litharge? Litharge was not unknown to the ancients; for it is mentioned by Dioscorides, Aëtius, and others. Sugar of lead is, indeed, more modern; but I have found no information respecting the invention of it, except that it was known to Paracelsus, who died in 1541, and who ventured to prescribe it for some disorders. It was known also to Angelus Sala, one of the most ingenious of the early chemists. In the Roman laws no particular orders occur against the adulteration or poisoning of wine; for what we read in the Institutiones[736] is applicable only to the spoiling of another person’s wine, and thereby occasioning a loss to him; and this explanation is confirmed by the Digesta[737]. The German prohibitions against the adulteration of wine began in the fifteenth century, and were from time to time renewed with additional severity. In that century, we find complaints against this practice with lime, sulphur, and milk; but no instance occurs of the poisoning with lead. I however conjecture that the use of litharge was introduced in the twelfth or thirteenth century; but the framers of the laws were not acquainted with the real poison; and instead of causing it to be examined by the chemists, who it must be confessed had not advanced far in their art, they contented themselves with prohibiting the use of those things which they found considered by the ancients as dangerous.