A Manual of Clinical DiagnosisTodd, James Campbell
Science
A Manual of Clinical Diagnosis
Todd, James Campbell
Diagnosis, Laboratory
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_Test_.--Three cubic centimeters of 10 per cent. solution of
ferrocyanid of potassium and 2 cubic centimeters of 50 per cent.
acetic acid are added to 10 cubic centimeters of the urine in the
percentage tube and _stood aside for ten minutes_, then placed in the
centrifuge and revolved at rate of speed and time as stated at head of
the table. If albumin is excessive, dilute the urine with water until
volume of albumin falls below 10 per cent. Multiply result by the
number of dilutions employed before using the table.
* * * * *
{76} (2) Mucin (Nucleo-albumin).--Traces of the substances which are
loosely classed under this name are present in normal urine; increased
amounts are observed in irritations and inflammations of the mucous
membrane of the urinary tract. They are of interest chiefly because
they may be mistaken for albumin in most of the tests. If the urine be
diluted with water and acidified with acetic acid, the appearance of a
white cloud indicates the presence of mucin.
(3) Albumoses.--These are intermediate products in the digestion of
proteids. They have been observed in the urine in febrile and
malignant diseases and chronic suppurations, but their clinical
significance is indefinite. The following is a simple test: Mix equal
parts of the urine, which has been strongly acidified with acetic
acid, and a saturated solution of sodium chlorid. A white cloud, which
appears upon moderate heating and disappears upon boiling, shows the
presence of albumose. If the cloud increases upon boiling, albumin is
present and should be removed by filtering while hot. The cloud due to
albumose will reappear as the filtrate cools.
2. Sugars.--Various sugars may at times be found in the urine. Glucose
is by far the most common, and is the only one of clinical importance.
Levulose, lactose, and some others are occasionally met with.
(1) Glucose (Dextrose).--It is probable that traces of glucose, too
small to respond to the ordinary tests, are present in the urine in
health. Its presence in appreciable amount constitutes "glycosuria."
_Transitory_ glycosuria is unimportant, and may occur in many
conditions, as after general anesthesia and {77} administration of
certain drugs, in pregnancy, and following shock and head injuries.
_Persistent_ glycosuria has been noted in brain injuries involving the
floor of the fourth ventricle. As a rule, however, persistent
glycosuria is diagnostic of diabetes mellitus, of which disease it is
the essential symptom. The amount of glucose eliminated in diabetes is
usually considerable, and is sometimes very large, reaching 500 gm.,
or even more in twenty-four hours, but it does not bear any uniform
relation to the severity of the disease. Glucose may, on the other
hand, be almost or entirely absent temporarily.
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