_Cancer_ of the penis is of two distinct kinds, occurring as scirrhus or as epithelioma. According to Dr. Walshe, the disease may originate as a warty excrescence, or as a pimple, which discharges an excoriating fluid, scabs, and breaks out afresh, while induration, followed by ulceration, advances at its base. Or it may infiltrate the glans, so as to convert that part into an indurated mass; or venereal ulcers may take on cancerous action. When of the _scirrhus_ form, it usually springs from the ulcers behind the glans, and may thence invade the neighboring parts of the organ. _Epithelioma_, commencing as a tubercle in the prepuce, may after a time give rise to a large, irregular, and sprouting mass, having a granular fungous appearance. In other cases, it commences as a hard scirrhus mass, of a pale, reddish-white color, situated on the glans, or between the prepuce and the glans. This increases in size, cracks, and allows the exudation of a serous fetid discharge. Ulceration then rapidly takes place. Secondary cancers, except in the adjacent glands, are not a common occurrence. Phymosis and the irritation caused by the retained secretion, seem to act as an exciting, and advancing age as a predisposing cause of cancer. _Encysted tumors_, _nævus_ and _fibro-plastic_ tumors, situated about the prepuce, may also occur. Section II. OF THE SCROTUM. [=Notice=: General condition; relaxed or contracted; œdema; cancer; tumors, etc.] =Hypertrophy.= _Common hypertrophy_ of the integument of the corium sometimes occurs; in this there is no alteration of the subcutaneous tissue. In _Elephantiasis_ of the scrotum, however, the epidermis, the corium, and the subcutaneous areolar tissue, are all, especially the latter, greatly hypertrophied. The areolar tissue is converted into a large mass of fibrous material, infiltrated with an albuminous and fibrinous fluid. “When the disease is confined to the scrotum, and the enlargement becomes great, the penis becomes drawn in and ultimately disappears, while the elongated prepuce is continuous at a navel-like opening in the skin of the surface of the tumor.” The enlargement sometimes is enormous, such a mass having been known to weigh two hundred pounds, more than the weight of the rest of the body. =Inflammatory Œdema= of the scrotum is an erysipelatous inflammation of this region, giving rise to great effusion into and swelling of the areolar tissue, with a tendency to the rapid formation of a slough, by which the integument may become so affected as to leave the testes and cords entirely denuded. A peculiar form of this disease occurs as a sequence of small-pox and scarlet fever. Here there is a tendency to speedy gangrenous disorganization of the areolar tissue, and of the covering of the generative organs. Morbid Growths.