=Congenital Anomalies.= The vesiculæ seminales participate in the defective development of the testes, being absent or imperfect when their related glands are so. =Inflammation.= It is not uncommon for these bodies to be attacked with chronic catarrhal inflammation, which causes a swelling of their mucous membrane, the secretion of unhealthy mucus, dilatation of the cavity, and thickening of its walls. Ulceration, perforation, and the formation of abscess in adjacent parts, may result. =Tubercular Deposits= are occasionally met with, chiefly in cases of extensive tuberculosis. “It appears as a thick, yellow, cheesy, lardaceous, fissured, purulent layer, replacing the mucous membrane.” It never occurs before puberty. The Prostate Gland. =Congenital Anomalies.= When the organs of generation are imperfectly developed, the prostate gland is generally found to be so too. =Hypertrophy and Atrophy.= _Hypertrophy_ is of frequent occurrence, especially in connection with old age. All the lobes may be enlarged equally, or nearly so, or one or the other of the lateral lobes alone, or the middle lobe, without any corresponding hypertrophy of the lateral. Hypertrophy of the middle lobe, when considerable, throws the neck of the bladder forward, and increases the depth of its lower region, so that calculi may lodge behind and below the prostate in its cavity. The canal of the urethra becomes lengthened in its prostatic portion, and may be narrowed by compression, or considerably dilated, so that the prostatic sinus may contain two or three ounces of urine. The retained urine decomposing, may cause irritation and inflammation of the bladder. The texture of the enlarged gland is generally indurated, though sometimes it is found to be looser and softer than natural. On section, the cut surface bulges above the level, and the shades of color are more strongly marked than in health. Frequently single gland-lobules are found hypertrophied. Small cavities, dilatations of the gland-follicles, are occasionally met with, sometimes empty and sometimes containing a yellow, pus-like fluid, the prostatic secretion in a thickened state. _Atrophy_, with consolidated texture, is found with atrophy of the testes. “_Eccentric atrophy_ is occasionally met with; the cavities are dilated and the walls thinned, in consequence of the increase in size of calculous concretions in its follicles. Cases sometimes occur, in which the whole of one lobe, or even the entire organ, is converted into a thin fibrous capsule, the proper substance of the gland being almost wasted.” =Inflammation.= As a result of suppressed gonorrhœal discharge, the prostate may be attacked with acute inflammation, followed by suppuration, or chronic enlargement, or an irritable state of the gland, with increased secretion.