The appearance presented by a clot, as well as the brain substance immediately around it, will vary according to the time the patient survives the attack. When death follows in a few days, the clot will have a soft, blackish appearance; after a month or six weeks, it becomes firm, and assumes a deep brown color, and at a still later period, it becomes still more firm, and of a pale red tint; lastly, it may become entirely absorbed. Peculiar changes also take place in the brain substance immediately around the clot, which vary according to the time intervening between extravasation and death. The portion immediately in contact with the clot is generally of a dark red or wine color, or, at a later period, of a chocolate brown, and of a soft, pulpy consistency. Exterior to this, the color is paler and of an orange tint, and still further on, of a bluish-white or yellow. The change in _structure_ and _consistence_ of the brain, immediately around the clot, constitutes one form of softening soon to be noticed. Section III. OF THE BRAIN. [=Notice= _before removal_—size; form; symmetry; space between surface of brain and calvarium. _After removal_—parts at base, their size, symmetry, color on surface, infiltration with serum or blood. _Removal of pia mater_—degree of adhesion; appearance of convolutions; color; consistence; effect of stream of water. Ulcers—condition of brain around. Sloughs—relation to membranes, condition of brain around. Deposits; tumors, wounds, etc. _After section, notice_ breadth and character of gray portions of convolutions; color, vascularity, etc. _Consistency_—softened or hardened; of white substance; color. _Blood-vessels_—number and size of red points in different portions. _Extravasation of blood_—its situation; fluid or coagulated; amount or size of coagulum; color, etc. Cavities in brain substance; their number, shape and contents. Blood, purulent, or fluid; its quantity and color. Condition of brain around; cicatrices; wounds; adventitious substances, as tumors, calcareous masses, tubercle cancer, etc. _Lateral ventricles_—note any difference in the two; contents; amount of serum or blood. _Choroid plexus_—pale or congested; cysts; calcareous bodies; their size and situation. _Lining membrane_ of ventricles; its vascularity, roughness, opacity, etc. _Septum lucidum_—entire or lacerated; consistence. _Fifth ventricle_—size, contents, etc. _Third ventricle_; contents. Commissures—their condition; middle, broken or double. _Optic thalami and corpora striati_—size, symmetry; character of surface and interior; if softened, extent; extravasation of blood, etc. Condition of _pineal gland_; _corpora quadrigemina_; _valve of Vieussens_, _etc._ _Medulla oblongata_—degree of adhesion of membranes; softening, exact locality of; condition about origin of nerves; appearance upon section. _Fourth ventricle_—contents; condition of floor, etc.