A case of moderate severity, with well-developed vesicles and characteristic grouping of lesions upon the face. [P.] V. Variola Vesiculosa. Fig. 1 shows a mixed eruption of papules and vesicles upon the right thigh. (Third day.) This condition is exceptional in Variola, though quite common in Varicella. [F.] Fig. 2 shows well developed umbilicated vesicles upon the forearm. (Fifth day.) [H.] Fig. 3 shows a hemorrhagic effusion into the vesicles on the thigh and leg, a condition far less serious than the purpuric eruption of malignant variola. [P.] VI. VARIOLA SEMI-CONFLUENS. (Fifth Day, Sixth Day.) These illustrations show a partly confluent character which the eruption frequently presents, even in mild cases, and especially upon the legs. The influence of pressure in developing a more profuse eruption may be noted above the ankles, where shoes were laced, and below the knees, where garters were worn. [F.] VII. VARIOLA CONFLUENS. (Seventh Day, Eighth Day.) Fig. 1 shows umbilicated pustules with an intense œdema of the foot, considerably increasing its size and causing much pain. Fig. 2 shows the epidermis raised in a large, irregular patch by the confluence of pustules. [F.] VIII. Variola Pustulosa. (Ninth Day.) Fig. 1 shows an eruption discrete upon the trunk and even upon the hand, while confluent upon the forearm. [H.] Fig. 2 shows a vaccine pustule coexisting with variolous pustules. The vaccination took place before the disease began, but too late to exert a decided prophylactic effect. [P.] Fig. 3 shows an eruption of large, flaccid pustules with swelling of the foot. [P.] Fig. 4 shows an eruption of discrete, tense, hemispherical pustules. [F.] IX. VARIOLA DISCRETA. (Ninth Day.) A typical case of mild smallpox occurring after vaccination and sometimes called Variola modificata or Varioloid. [P.] X. VARIOLA PUSTULOSA. (Tenth Day.) A severe case, showing the characteristic aggregation of lesions on the face and extremities. [P.] XI. VARIOLA PUSTULOSA. (Ninth Day, Tenth Day, Eleventh Day.) These illustrations show the pustular lesions in the stages of complete distention, when they present a rounded appearance, and of incipient desiccation, when they appear flattened and with a central depression or “secondary umbilication.” [P., F., F.] XII. Variola Pustulosa et Crustosa. (Tenth Day, Twelfth Day.) In Fig. 1 an occlusion of the nasal passages is indicated by the lips parted in respiration. [P.] Fig. 2. shows a palmar condition which, in the adult, is found only in smallpox. [P.] Fig. 3 shows the desiccation of the facial eruption in advance of other regions. [P.] Fig. 4 shows a mild discrete case in which a diagnosis of acne had been made. [F.] Fig. 5 shows the eruption in the stage of desiccation. [F.] XIII. VARIOLA CRUSTOSA. (Eighteenth Day.)