In this paper we are presenting a taxonomic review of the genus _Osteocephalus_; of necessity our study has been at the alpha level. We have utilized all of the usual external characters, as well as osteological features in our definitions of the species. Tadpoles and mating calls are available for only one species, _O. verrucigerus_ (Trueb and Duellman, 1970); these and other important systematic characters, such as karyotypes, are not available for the group at this time. Our tendency has been to take a conservative view of species; thus it is doubtful that any subsequent worker will recognize fewer species in the genus. Our observations on these frogs in Amazonian Ecuador are presented in a final section of this paper. ACKNOWLEDGMENTS For the loan of specimens or for the provision of working space in their respective institutions, we are indebted to James E. Boehlke, Werner C. A. Bokermann, F. W. Braestrup, Nelly Carrillo de Espinoza, Osvaldo R. da Cunha, Josef Eiselt, M. J. Fouquette, Jr., Alice G. C. Grandison, Jean Guibe, Birgitta Hansson, Walter Hellmich, M. J. Hoogmoed, Robert F. Inger, Konrad Klemmer, Jean Lescure, Alan E. Leviton, Clarence J. McCoy, Robert H. Mount, Charles W. Myers, Umberto Parenti, Guenther Peters, James A. Peters, William F. Pyburn, Juan A. Rivero, Dorothy M. Smith, Paulo E. Vanzolini, Greta Vestergren, David B. Wake, Charles F. Walker, Ernest E. Williams, and Richard G. Zweifel. Study of specimens in European museums was made possible by a grant (No. 5063) from the Penrose Fund of the American Philosophical Society. Field work in Ecuador was partially supported by grants from the Watkins Fund of the Museum of Natural History, University of Kansas. At our base camp at Santa Cecilia, Ecuador, we enjoyed the hospitality of Ing. Ildefonso Munoz B. Transportation in Ecuador was generously provided by the Texaco Petroleum Company. During the course of our field work Stephen R. Edwards and Thomas H. Fritts contributed directly to our study of _Osteocephalus_. Michael J. Tyler of the South Australian Museum provided information on the vocal sac structure. We extend our sincere thanks to all of these persons for their contributions to our endeavors. MATERIALS AND METHODS