The difficulties and sufferings, which have accrued to American women, from this cause, are almost incalculable. There is nothing, which so much demands system and regularity, as the affairs of a housekeeper, made up, as they are, of ten thousand desultory and minute items; and yet, this perpetually fluctuating state of society seems forever to bar any such system and regularity. The anxieties, vexations, perplexities, and even hard labor, which come upon American women, from this state of domestic service, are endless; and many a woman has, in consequence, been disheartened, discouraged, and ruined in health. The only wonder is, that, amid so many real difficulties, American women are still able to maintain such a character for energy, fortitude, and amiableness, as is universally allowed to be their due. But the second, and still greater difficulty, peculiar to American women, is, a delicacy of constitution, which renders them early victims to disease and decay. The fact that the women of this Country are unusually subject to disease, and that their beauty and youthfulness are of shorter continuance than those of the women of other nations, is one which always attracts the attention of foreigners; while medical men and philanthropists are constantly giving fearful monitions as to the extent and alarming increase of this evil. Investigations make it evident, that a large proportion of young ladies, from the wealthier classes, have the incipient stages of curvature of the spine, one of the most sure and fruitful causes of future disease and decay. The writer has heard medical men, who have made extensive inquiries, say, that a very large proportion of the young women at boarding schools, are affected in this way, while many other indications of disease and debility exist, in cases where this particular evil cannot be detected. In consequence of this enfeebled state of their constitutions, induced by a neglect of their physical education, as soon as they are called to the responsibilities and trials of domestic life, their constitution fails, and their whole existence is rendered a burden. For no woman can enjoy existence, when disease throws a dark cloud over the mind, and incapacitates her for the proper discharge of every duty. The writer, who for some ten years has had the charge of an institution, consisting of young ladies from almost every State in the Union, since relinquishing that charge, has travelled and visited extensively in most of the non-slaveholding States. In these circuits, she has learned the domestic history, not merely of her pupils, but of many other young wives and mothers, whose sorrowful experience has come to her knowledge. And the impression, produced by the dreadful extent of this evil, has at times been almost overwhelming.