RICHARD MACIFF, æt. 30, admitted on the 22d day of fever. No account can be obtained of its previous history: at present he lies quite prostrate and perfectly insensible; eyes wild and rolling; pupils dilated and insensible to light; constantly picking at the objects around him; pulse not to be counted, on account of his extreme restlessness, but it feels like a soft cotton cord, and nearly without pulsation. 23d. Profound coma; senseless muttering; constant muscular tremor; squinting; neither stool nor urine has been passed since admission; pulse 96, soft, not intermittent. 24th. Coma undiminished; one stool passed in bed; urine drawn off by the catheter; pulse 100, extremely feeble. 25th. No change. 26th. Died. _Head._ Dura mater vascular; arachnoid highly vascular; that portion of it covering the tuber annulare distended into a bag of considerable size, filled with serum; all the ventricles enlarged and distended with serum. _Thorax._ [Right lung contained tubercles in various stages of disease.] _Abdomen._ [Liver of unusually deep red colour; in right and left lobes two small sacs, filled with calcareous matter; on surface of spleen a sac, containing matter similar to that in the liver.] CASE XXXIX. WILLIAM TENNANT, æt. 18, tailor. Admitted on the 8th day of fever; at present much pain of head back, and extremities; no sleep; face flushed; epigastrium tender: tongue red round margin, coated in middle; much thirst; pulse 99. V.S. ad ℥x. 9th. Pain of head continues; scarcely any sleep; pulse 96. C.C. ad ℥x. nuchæ. 10th. Pain of head unrelieved, particularly severe over the forehead; face flushed; tongue brown and dry; pulse 92. 11th. Pain of head quite gone; no longer conscious of any uneasiness in the limbs; much drowsiness; delirium; pulse 104. 12th. Rather more sensible; delirium; tongue unchanged; stools and urine passed in bed; pulse 112. 13th. Delirium increased; eyes glistening; pulse 120. 14th. Mind more distinct this morning; much delirium through the night; respiration hurried; pulse 130. Died next morning. _Head._ Membranes and substance healthy; on the under surface of right hemisphere, corresponding with the middle lobe, a remarkably deep and extensive depression, the deepest part corresponding to the centre of the brain; this depression was lined with the arachnoid, which being reflected formed a sac, that contained 12 ounces of serous fluid, and completely filled the cavity. The cerebral substance beneath and around was perfectly sound and entire. _Thorax._ Viscera healthy. _Abdomen._ Mucous membrane of ilium and cæcum extensively and greatly ulcerated. 4. _Vascularity &c. with preternatural Firmness of Brain._ CASE XL.