The disorder of his mind was not less than that of his body; without ideas, without memory, without reflections, without anxiety about his fate, without any other sensation but that of a pain which returned with every fit, at least once in three days. A being much below that of a brute; a sight, of which there is no conception can reach the horror. It was not easy to make out that he had ever belonged to the human species. I procured for him quickly enough the relief of destroying those violent convulsive fits, which recalled him to the power of feeling, only by the pain they brought with them; but satisfied with having mitigated his tortures, I discontinued remedies, which could have no efficacy on the main of his disorder. He died at the end of a few weeks, in June, 1757, œdematous all over his body. Not all those who give themselves up to this odious and criminal habit, are, it is true, so severely punished; but there are none that do not suffer for it in a less or greater degree. The frequency of the act, the difference of constitutions, many adventitious circumstances, may occasion considerable differences. The pernicious consequences that have fallen under my observation, are, _first_, a total disorder of the stomach, which in some discovers itself by loss of appetite, or by a depravation or irregularity of its cravings; in others, by acute pains, especially in the time of digestion, by habitual nauseas or vomitings, which resist all remedies, while the cause, the bad practice, is continued. _Secondly_, A weakening of the organs of respiration, whence frequently result dry husky coughs, almost always a hoarseness, a failure of voice, and a shortness of breath, on any little violence of motion. _Thirdly_, A total relaxation of the nervous system. It does not require a very deep knowledge of the animal œconomy, to be sensible that the three prementioned causes are capable of producing all the diseases of languor, and experience every day proves their producing them. The first ill consequences of them, to such as are guilty of self-pollution, besides those I have just pointed out, are a considerable diminution of strength, a less or greater paleness, sometimes a slight but continual jaundice, often pimples, which come and disappear only to make room for fresh ones, and are constantly reproducing themselves all over the face, but especially in the forehead, the temples, and about the nose; a notable leanness; an astonishing sensibility to the changes of weather, especially to cold; a languor in the eyes, a weakening of the sight, a great impairment of the faculties, especially of the memory. “I am sensible (a patient writes me) that this wretched practice has diminished the strength of my intellectual faculties, and especially of my memory[35].”