On the 10th of February, 1760, I was called to visit, in the country, a man of about forty years of age, who had been very strong and robust, but who had been guilty of great excesses with women and wine, and who had moreover often exercised himself at trials of bodily strength. It was some months precedently that his disorder had begun by a weakness in his legs which made him stagger as he walked, as if he had been drunk. Sometimes he would actually fall down, though on the plainest ground. He could not descend any steps without a great deal of trouble, and hardly durst stir out of his apartment. His hands shook terribly; it was with much difficulty he could write a few words, and those sadly scrawled. But he could dictate readily enough, though his tongue, which had never had any great volubility, began to have rather somewhat less. His memory was good, and the only thing that could make any detriment to his intellects to be suspected, was, that he was less attentive to the _game of draughts_, and that his countenance was a good deal altered. He had an appetite, and slept; but it was with difficulty he could turn himself in his bed. It appeared to me, that his excesses with women and wine were the primary cause of his disorder, and I judged, that his straining in his trials of bodily strength might be the reason why his muscles were more particularly attacked. The season was rather unfavorable to the employment of remedies, and yet it was requisite, in the mean while, to stop the progress of the disease. I advised him frictions of the whole body, with flannel, and other corroboratives; proposing to myself to augment the doses with the adjunction of the cold-bath, in the beginning of the summer. At the end of some weeks the tremors of his hand appeared some what abated. In the month of April there was a conciliation held on him, in which his disorder was imputed to an accident of his having, about two years before, written, for some months, in a room newly plaistered and damp. Upon this there were applied warm baths, unctuous frictions, powders said to be diaphoretic and antispasmodic; but no alteration for the better followed. In the month of June, a second consultation decided for his going to the baths of Leuk, in Valais: he went, and on his return he had more tremors, and a greater stiffness. Since then (September, 1760) till the month of January 1764, I have not seen him above three or four times.