The weakness which is produced by self-pollution, is attended with such a difficulty in the choice of restorative remedies, as does not occur in other cases; which is, that those articles must, with the greatest care, be avoided, that, bringing with them any irritation, might awaken the sensual passion. In the animal mechanism, that mechanism so different from the inanimate, and so little subjected to the same rules, there is a law, that, when the motions augment, the augmentation is the most considerable in the parts the most susceptible. In self-polluters those parts are the generative ones. It is in these parts that the effect of the irritating remedies will the most sensibly manifest itself; and the dangerous consequences of this effect cannot be too circumstantially guarded against in the choice of the means of cure. What then are they to be? This is what I shall examine, after having particularised the regimen. In this particularisation, I shall follow the common division of the six non-naturals, as they are termed, Air, Aliments, Rest, Motion, the natural Evacuations, and the Passions. _AIR._ Air has the influence over us, that water has over fish, and even a much more considerable one. Those who know how great a power the air has, and who also know that there have been Epicures who could, by the taste, discover not only the river, but even the part of the river out of which the fish had been taken; ——_lupus hic Tiberinus an alto_ _Captus hiet, pontesne inter jactatus an amnis_ _Ostia sub Tusci?_ HOR. such, I say, will easily be sensible of the importance it is of to the sick, their breathing one air preferable to another. Such as may have once entered into a room inhabited without being aired; such as may have kept walking on the side of a marsh in the heats; or have resided in low places, surrounded, on all sides, with eminences; such as have made a transition from a populous town to the country; who have breathed the air at sun-rise or at mid-day, before or after a shower of rain; all these, I say, will conceive how great an influence the air has over health. _Temperie cœli corpusque, animusque juvatur._ OVID.