This case shows us paralysis confined at first to the abdominal limbs, but extending afterward to the upper part of the body. We find a similar case of this progression, in a case related by Olivier, of Angers:-- “M--, of a sanguine temperament, of a strong constitution, and of a lively and gay character, had always enjoyed good health until seventeen years old, when he unfortunately became addicted to masturbation. He soon languished, and grew debilitated. Having, however, conquered this fatal habit, his strength gradually returned, and a proper regimen soon restored him to his former vigor. When twenty years old, he perceived a marked debility in the motions of the articulation of the right foot; but this disappeared: he was then affected twice with blenorrhagia, the last attack of which continued for several months. “When twenty-five years old, he again indulged in masturbation, and similar symptoms to those first presented soon appeared: the lower extremities, also, became weakened; at times, also, the sensibility of the skin was obtuse, and even lost; but it soon reappeared. Under the influence of remedies, the weakness in the limbs diminished slightly. M-- could walk three quarters of an hour without resting, but he could not stand longer; his legs, which were evidently wasted, refusing to sustain him. He was extremely costive; and since the last attack of blenorrhagia, the excretion of urine was painful. “This affection remained stationary for several years, and then became more serious: the patient was now twenty-nine years old. At this period, the paraplegia became complete. He could not walk, nor even support himself on crutches; his lower limbs were often stiff; both arms, also, were at times insensible; and sometimes the sense of touch was blunted. The wasting away had increased; the excretion of urine was often involuntary, and the constipation was habitual. He was somewhat benefited by Hallé’s prescriptions, consisting in frictions with cantharides, and douches to the spine; but the next year the evil increased, the sensibility in the hands diminished, and there was difficulty in moving the right hand. “Eighteen months afterward, the lower extremities became perfectly paralyzed: they were less warm than the rest of the body; yet, when cold water was applied to them, it produced a burning sensation. The right arm, forearm, and hand, often felt fatigue: its motions were less free, and the patient sometimes found it difficult to write. The limb of the opposite side was not affected. The disease of the bladder, which had existed for several years, was also increased.