the vanity, pride and luxury which produces great cities; and the same vanity, &c. joined with avarice, which gives life to commerce. Add to all this the neglect of the cultivation of the earth, which ought to be the principal business of man. In consequence of this neglect, immense tracts of it are still overrun with woods, covered with stagnant and noxious waters, or lying in waste and now uninhabitable deserts, fit only for serpents and the most destructive animals. Thus the very climate is changed from what it ought to be; the elements become hostile to man in an extreme degree, and the whole system of nature, originally designed to give life and happiness to the human race, is, through their own misconduct, changed into a system of misery, disease and death. The account just now given of the ways in which mankind bring upon themselves the plague, and other diseases almost equally terrible, is so conformable to the opinions of the learned Dr. Mead, that I shall conclude this section with a few extracts from his works. Of the small pox he says, that he supposes this “to be a plague of its own kind, originally bred in Africa, and more especially in Ethiopia, as the heat is excessive there; and thence, like the true plague, was brought into Arabia and Egypt, after the manner above mentioned” (i. e. by war and merchandise.) “Now (adds he) if any one should wonder why this contagion was so long confined to its native soil, without spreading into distant countries, I pray him to consider, that foreign commerce was much more sparingly carried on in ancient times than in our days, especially between Mediterranean nations; and likewise that the ancients seldom or never undertook long voyages by sea, as we do. And Ludolfus observes, that the Ethiopians in particular were ignorant of mercantile affairs. Therefore when in process of time the mutual intercourse of different nations became more frequent by wars, trade and other causes, this contagious disease was spread far and wide. But, towards the end of the eleventh century, and beginning of the twelfth, it gained vast ground by means of the wars waged by a confederacy of christian powers against the Saracens, for the recovery of the Holy Land; this being the only visible recompense of their religious expeditions, which they brought back to their respective countries.” Of the true plague he says, “It appears, I think, very plainly, that the plague is a real poison, which, being bred in the southern parts of the world, is carried by commerce into other parts of the world, particularly into Turky, where it maintains itself by a kind of circulation from persons to goods; which is chiefly owing to the negligence of the people there, who are stupidly careless in the affair: that, when the constitution of the air happens to favour infection, it rages there with great violence; that at that time, more especially, diseased persons give it to one another, and from