of Nerves of _Spigellius_, or the first of _Bartholin_, which are appropriated to Smelling, that it gradually impairs, and, in process of Time, totally destroys that Sense; because this Pair of Nerves is conveyed to the mamillary Processes, which are situated in the interior Part of the Brain, near the _Os Ethmoides_, which is covered with the _Dura Mater_. Since, therefore, a large Quantity of Snuff is violently attracted towards the Root of the Nose; and since, according to the Doctrine of _Hippocrates_, Nature is never one Moment idle in a living Body, all whose Parts are pervious and transparable, it must necessarily happen, that the Parts subservient to the Sense of Smelling must be greatly injured by the narcotic Quality of Snuff. Having said thus much of the Misfortunes produced by excessive Snuffing, we now come to consider those attending the Abuse of Smoaking; in doing which, we shall confine ourselves to Examples, which have a better Effect on the Vulgar, than the nice and fine-spun Deductions of a Philosopher's Reason. It is therefore certain that _Tobacco_ is possessed of an highly penetrating Quality. Thus the celebrated _Heurnius_, in _Lib. 1. Method. ad Prax._ speaks of it in the following Manner: "_Tobacco_, when smoaked, produces very singular Effects, since it draws a surprizing Quantity of Phlegm from the Mouth and Nostrils: The Smoak arising from its dry Leaves laid upon live Coals, when received into the Mouth by a Funnel, pervades the whole Brain, and is also conveyed to the Ears, and _Uterus_. But I can affirm, that this Herb is, in a peculiar Manner, appropriated to the Brain; easily conveys its Virtues thither, and evacuates all its _Sordes_: For, about a Year ago, when I was afflicted with the Tooth-ach, I made a Decoction of _Tobacco_ with Water, adding some _Camomile_ Flowers: A Spoonful of this Decoction, when tepid, I put in my Mouth, and spit it out some Time after; and this I did for two Hours; by which Means my Pain was considerably alleviated. Next Day, when I went to my Garden, and stooped to pull up a Weed, a large Quantity of a Saffron-coloured Liquor, which smelled like _Tobacco_, flowed from my Nose, upon which my Tooth-ach was immediately removed. During the whole of my Life, neither Blood, nor any other Liquor, except a ferous Phlegm, had flowed from my Nose, but upon this Occasion I never saw any Liquor of a deeper yellow Colour." Other similar Accounts of the penetrating Quality of _Tobacco_, I have had from my old Master, _Henningus Arnesæus_, Physician to _Christianus_, the fourth King of _Denmark_, who affirmed, "That not only the Smoak of _Tobacco_, but also that of every other Substance received by the Mouth, was penetrating on Account of its Acrimony; in Consequence of which, it must pervade and alter the whole Substance of the Brain, both _Meninges_, and all the Vessels, and Contents of them." Besides, as the Smoak of _Tobacco_ is hot, proceeding immediately