The itch, or mange (scabies), is caused by the irritation which the mites continually exert on the skin. The warmer the surroundings of the host, the more active the mites, and the more painful the skin disease. (The scarcoptes mites, _e.g._, are most unendurable in man when in bed, and scabby sheep are most tormented when in a warm fold.) The mites multiply with such enormous rapidity that it is easy to understand how a single fertilized female, transferred to a new host by contact with an affected animal, is able, in a short time, to make large patches of the skin mangy. The course of the disease is generally as follows:—Soon after infection small swellings appear, which become little bladders of the size of a pin’s head. These burst, and the affected parts of the skin are quickly covered with a crust formed from shrivelled bits of skin and dried-up fluid. In many places the attacked parts of the skin are moist, for the host, in consequence of the severe itching, rubs or knocks itself. In consequence of the shedding of fluid the hairs stick together, and later on fall out. The skin thickens, becomes encrusted, and is thrown into folds, between which there are deep cracks. Among domesticated animals the sheep is certainly the one which suffers most from scabies (_Dermatocoptes_), especially as the disease spreads rapidly in the warm sheltering fleece, which also makes the removal of the parasites a matter of the greatest difficulty. The wool gets dry and brittle in the diseased parts, and its fibres become loose, though they remain attached for a short time, since their tips are glued together by the sticky substance which exudes from the little thickenings in the skin. They gradually fall out, however, leaving the skin covered with a thick brownish crust, looking as if it were soaked with oil. Badly infested sheep get thin and even die. This, however, is not usually the case, and the injury consists in the great deterioration of the wool, both as regards quantity and quality. The following summarizes the kinds of scabies affecting man and domestic animals, and indicates how far one kind of host can affect another:— Itch of =Man= (_Sarcoptes_) can be caught by the dog, but by no other domestic animal. Scabies of the =Horse=.—The sarcoptes mange of this animal is contagious for man, and for the ox, but no other domestic animal. The dermatocoptes mange (found more particularly on the inner sides of the legs, and on the genital organs, tail, and mane) does not spread to man or to other domestic animals. Nor is this the case with the dermatophagus mange of the horse (on the fetlocks and adjacent parts of the legs). Scabies of the =Ox=.—The dermatocoptes mange of the ox (chiefly affecting the sides of the neck and root of the tail) spreads to men and horses, but not to sheep. The dermatophagus mange (principally on the root of the tail and near the anus) does not seem to be transmitted to man, horse, pig, or dog.