Who shall say where end the consequences of alcoholic injury of the blood and of the substance of the brain? Here within the cranium, in this narrow chamber, so small that a man's hand may span it, and upon this sheet of cerebral matter, which, if dilated out, would not cover a surface of over six hundred square inches, is the point of union between spirit and matter. Inversions of right judgment and every distortion of moral sense legitimately follow from the intoxicating cup. It is here that we should speak decidedly of the evil effects of moderate drinking. Men may theorize as they please, but practically there is in average experience no such thing as a moderate dose of alcohol. People drink it to produce an effect. They take enough to "fire up," as they say, and unless that effect is produced they are not satisfied. They will have enough to raise their spirits, or dissipate gloom. And this is enough to impair judgment, and in the course of years perhaps to ruin fortune, body, and soul. The compass is out of line in life's dangerous sea, and a few storms may bring the ship upon breakers. It is to be remembered that, by the law of local affinity, the dose of alcohol is not diffused throughout the system, but is concentrated in its chief effects upon a single organ. When a man drinks moderately, though the effects might be minute if dispersed through the whole body, yet they may be powerful when most of them are gathered upon the brain. They may be dangerous when turned upon the intellect, and even fatal when concentrated upon the primal guiding powers of mind--reason, and moral sense. It is not to the whole body that a moderate glass goes; it is chiefly to its most important part--the brain; and not to the whole brain, but to its most important part--the seat of the higher mental and moral powers; and not to these powers at large, but to their helmsman and captain--Reason and Conscience.