The ingestion of a large food mass produces usually a marked change in streaming. A more or less spherical form is assumed, and if the food mass be a live organism such as a large ciliate, the ameba frequently remains quiet for a considerable interval. If a large amount of food is eaten, as for example a dozen or two colpidia, the ameba may suspend concerted streaming for an hour or more. During this time small pseudopods are projected here and there, but there is no locomotion. But if an ameba eats large masses of carmine, there is usually no pause following ingestion, and the same thing is true when the ameba is induced to eat bits of glass and other indigestible substances. It follows therefore that the interrupted streaming of the endoplasm due to feeding is not caused by the act of ingestion as such, but rather by the onset and continuance of the normal digestive processes on a large scale. These reactions are again strikingly similar to what is observed in many vertebrates, in which a more or less definite body sense, whose sense organs are in the splanchnic region, is supposed to be involved; but what the explanation of similar behavior in ameba is, is not at all clear. Another factor of great importance in endoplasmic streaming is the nucleus. It was observed by Hofer (’90) that amebas lacking nuclei did not move in a coordinated manner. Štolc (’10) however records a number of observations in which characteristic movement was observed in enucleate amebas ten or more days after the enucleate ameba had been cut off from a normal ameba. Hofer’s amebas died after nine or ten days, while Štolc’s remained alive, some of them for over thirty days. Recently Willis (’16) confirmed Hofer’s findings, but does not discuss Štolc’s results. The cutting of an ameba into two pieces, one with and the other without a nucleus, is a very simple operation. It is also very easy to observe that within an hour or so the enucleate ameba does not move normally, and that there is no concerted endoplasmic streaming while the nucleate ameba seems to behave normally. But Štolc’s contention that enucleate amebas move characteristically (l. c., p. 159, 160, 167) is not necessarily contradicted by these observations, for Štolc’s observations refer to amebas that lived much longer than the enucleate amebas of Hofer and of Willis. Even if an enucleate ameba is able to recover, after many days, its power of concerted movement, there can be no doubt that enucleate amebas do not move characteristically for a short time after the operation, and that this effect is due to the lack of a nucleus.