Bibliography 146 CHAPTER I INTRODUCTION The manner of movement common to amebas has attracted the attention of biologists ever since the discovery of ameba by Rösel v. Rosenhof in 1755. In his description of “Der kleine Proteus” he records the observation that the various form changes which the ameba undergoes are associated with the streaming of the endoplasm. This observation marks the very beginning of the investigation of ameboid movement. And this investigation also possesses the distinction of being the most important single observation that has thus far been recorded in this special field, for it is now generally understood that by ameboid movement is meant movement due to the streaming of protoplasm. The phenomenon of ameboid movement as discovered by v. Rosenhof, was an isolated phenomenon. It attracted attention mainly because of its uniqueness, for it was the only instance of the kind that was then known. It could not be compared with any other form of movement; and the animal itself, considered apart from the streaming of the protoplasm, was unique also, because of its remarkable form changes which it alone, of all the animals then known, exhibited. But when Corti in 1774 discovered streaming protoplasm in the cells of chara and various other plants, the ameba could no longer be said to occupy this position of isolation. Although streaming is not accompanied by locomotion in chara, it had been observed that movement in the ameba was always accompanied by streaming, so it came to be generally accepted that the really fundamental feature of ameboid movement was the streaming of the protoplasm. The ameba came to be of especial interest to the physiologists later on when the finer structures of the larger animals were studied more carefully. Thus when the normal movements of the white blood corpuscles were discovered, no one failed to be struck with their ameboid characteristics in almost every detail of movement, feeding habits and gross structure. The great importance of the functions that have been ascribed to leukocytes, and their very widespread occurrence in the higher animals has served to give rise to the belief that ameboid characteristics were not unique among animals, but common to many of them. The discovery of ameboid movements among plant zoospores, among animal ova, in the endoderm cells lining the digestive tract of a great variety of animals, in the nuclei of some animal cells, in the wandering cells of sponges and other animals--all these instances of ameboid movement occurring in such widely different tissues inevitably placed it among the most important phenomena known to occur in organisms.