The mode by which the Eastern Inoculators convey the variolous taint into the blood, has nothing uncommon in it, unless we except the preceding friction upon the part intended for Inoculation, and moistening the saturated pledget, before the application of it; for this practice they alledge the following reasons; that by _friction_ the circulation in the small sanguinary vessels is accelerated, and the matter being _diluted_ by a small portion of _Ganges water_, is, from both causes, more readily and eagerly received, and the operation at the same time sanctified. The friction and dilution of the matter, has certainly the sanction of very good common sense; and the Ganges water, I doubt not, may have as much efficacy as any other _holy water_ whatsoever. This last circumstance, however, keeps up the piety and solemnity with which the operation is conducted from the beginning to the end of it; it tends also to give confidence to the patient, and so far is very laudable. The reasons they assign for giving the preference to matter of the _preceding year_, are singular and judicious; they urge, it is more certain in its effects; that necessity first pointed out the fact, (the variolous matter some years not being procurable,) and experience confirmed it: they add, that when the matter is effectually secured from the air, it undergoes at the return of the season an _imperceptible fermentation_, which gives fresh vigour to its action. It is no uncommon thing to inoculate with matter four or five years old, but they generally prefer that of a year old, conceiving that the fermentation which constitutes its superiority over fresh matter, is yearly lessened, and consequently the essential spirit of action weakened, after the first year.