So great is the dependence which the Eastern Practitioners have on opening the Pustules, in every malignant kind of the disease, that where the fluid state of the matter has been suffered to elapse without being evacuated, they pronounce the issue fatal, and it generally proves so; they order it in every kind, even the most distinct; for although in these it should seem scarcely necessary, yet they conceive it effectually prevents inflammation and weakness of the eyes, biles, and other eruptions and disorders, which so commonly succeed the disease, however benign; in very critical cases, they will not trust the operation of opening the Pustules to the nurses or relations, but engage in it themselves, with amazing patience and solicitude; and I have frequently known them thus employed for many hours together; and when it has been zealously persevered in, I hardly ever knew it fail, of either intirely preventing the _second fever_, or mitigating it in such sort, as to render it of no consequence; in various instances, which I have been a witness to, in my own, and others practice, I have seen the Pustules in the _contiguous_ kind, upon being successively opened, fill again to the fourth and fifth, and in the _confluent_, to the sixth, seventh, and eighth time; in the very distinct sort they will not fill again more than once or twice, and sometimes not at all, which was a plain indication, that the whole virus of the disease was excelled in the first eruption. The Eastern Practitioners, with great modesty, arraign the European practice of Phlebotomy and Cathartics in any stage of the disease, but more particularly when designed to prevent, or mitigate the second fever; alledging, that the _first_ weakens the natural powers, and that the _latter_ counteracts the regular course of _nature_, which in this disease invariably tends to throw out the offending cause _upon the skin_; that she often proves unequal to the intire expulsion of the enemy, in which case, her wise purposes are to be assisted by art, in that track, which she herself points out, and not by a diversion of the usual crisis into another chanel; that this assistance can only be attempted with propriety, by emptying the Pustules, as thereby fresh room is given in them for the reception of the circulating matter still remaining in the blood, and which could not be contained in the first eruption; by which means every end and purpose of averting, or subduing the _second fever_ is obtained, with a moral certainty; whilst Phlebotomy and Cathartics, administered with this view, are both irrational and precarious; as being opposite to the constant operation of Nature in her management of this dreadful disease.